Journal of Neurology

, 257:59 | Cite as

Antineuronal antibodies in sporadic late-onset cerebellar ataxia

Original Communication

Abstract

Sporadic late-onset cerebellar ataxia of unknown cause is considered a neurodegenerative disorder whose underlying mechanisms are still unknown. To identify antineuronal autoantibodies, immunohistochemical and immunoblotting techniques were performed in 67 patients with sporadic cerebellar degeneration of unknown cause. Elevated P/Q-type voltage-gated calcium channel (VGCC)-specific antibodies were found in eight patients (11.9%). There was no hint of a paraneoplastic disorder in any of the patients. The present findings suggest an autoimmune contribution to the pathophysiology of a subgroup of sporadic late-onset cerebellar ataxia.

Keywords

Voltage-gated calcium channels VGCC Idiopathic late onset cerebellar ataxia Multiple system atrophy Paraneoplastic cerebellar degeneration 

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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • K. Bürk
    • 1
    • 2
    • 3
  • M. Wick
    • 4
  • G. Roth
    • 5
  • P. Decker
    • 1
  • R. Voltz
    • 6
    • 7
  1. 1.Institute for Cell Biology, Department of ImmunologyUniversity of TübingenTübingenGermany
  2. 2.Institute of Brain ResearchUniversity of TübingenTübingenGermany
  3. 3.Department of NeurologyUniversity of MarburgMarburgGermany
  4. 4.Department of Laboratory MedicineUniversity of MunichMunichGermany
  5. 5.Department of Microsystems EngineeringUniversity of FreiburgFreiburgGermany
  6. 6.Department of NeuroimmunologyUniversity of MunichMunichGermany
  7. 7.Department of Palliative MedicineUniversity of CologneCologneGermany

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