Antineuronal antibodies in sporadic late-onset cerebellar ataxia
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Sporadic late-onset cerebellar ataxia of unknown cause is considered a neurodegenerative disorder whose underlying mechanisms are still unknown. To identify antineuronal autoantibodies, immunohistochemical and immunoblotting techniques were performed in 67 patients with sporadic cerebellar degeneration of unknown cause. Elevated P/Q-type voltage-gated calcium channel (VGCC)-specific antibodies were found in eight patients (11.9%). There was no hint of a paraneoplastic disorder in any of the patients. The present findings suggest an autoimmune contribution to the pathophysiology of a subgroup of sporadic late-onset cerebellar ataxia.
KeywordsVoltage-gated calcium channels VGCC Idiopathic late onset cerebellar ataxia Multiple system atrophy Paraneoplastic cerebellar degeneration
This study was supported by the Deutsche Forschungsgemeinschaft DFG (project D7, SFB571 Autoimmunität, RV) and the Herrmann and Lilly Schilling Foundation. We thank Prof. Dr. Hans-Georg Rammensee for critical reading of the manuscript.
Conflict of interest statement