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Journal of Neurology

, Volume 256, Supplement 3, pp 310–316 | Cite as

Lack of functional relevance of isolated cell damage in transplants of Parkinson’s disease patients

  • Oliver Cooper
  • Arnar Astradsson
  • Penny Hallett
  • Harold Robertson
  • Ivar Mendez
  • Ole IsacsonEmail author
Article

Abstract

Postmortem analyses from clinical neural transplantation trials of several subjects with Parkinson’s disease revealed surviving grafted dopaminergic neurons after more than a decade. A subset of these subjects displayed isolated dopaminergic neurons within the grafts that contained Lewy body-like structures. In this review, we discuss why this isolated cell damage is unlikely to affect the overall graft function and how we can use these observations to help us to understand age-related neurodegeneration and refine our future cell replacement therapies.

Keywords

Cell transplantation Lewy body Therapy Dopaminergic 

Notes

Conflict of interest statement

The authors declare no conflict of interest.

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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Oliver Cooper
    • 1
  • Arnar Astradsson
    • 1
  • Penny Hallett
    • 1
  • Harold Robertson
    • 2
  • Ivar Mendez
    • 3
  • Ole Isacson
    • 1
    Email author
  1. 1.Center for Neuroregeneration Research, NINDS Udall Parkinson’s Disease Research Center of Excellence, McLean Hospital, Harvard Medical SchoolHarvard UniversityBelmontUSA
  2. 2.Department of PharmacologyDalhousie UniversityHalifaxCanada
  3. 3.Division of Neurosurgery and Neuroscience, Queen Elizabeth II Health Science CenterDalhousie UniversityHalifaxCanada

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