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Journal of Neurology

, Volume 256, Issue 11, pp 1924–1925 | Cite as

Tremor in Klinefelter’s syndrome improved by testosterone administration

  • Hiroyuki KinoshitaEmail author
  • Takuya Ohkubo
  • Masakazu Kaneko
  • Nozomu Satoh
  • Saneyuki Mizutani
  • Mutsuko Yasuda
  • Akira Machida
  • Kinya Ishikawa
  • Tomoyuki Kamata
  • Fumiatsu Yakushiji
Letter to the Editors

Abstract

Tremor in Klinefelter’s syndrome is believed to be essential tremor since the publication of “Klinefelter’s syndrome and essential tremor” in 1969. However, the author also stated that tremor in Klinefelter’s syndrome might differ from essential tremor. A 71-year-old man with Klinefelter’s syndrome who suffers from postural hand tremor is described. The electromyogram indicated lower motor neuron disturbance and chronic neurogenic change. The muscle biopsy indicated neurogenic muscle atrophy. Upon testosterone administration, the amplitude of tremor was reduced and a gradual improvement in handwriting was observed. The tremor in this patient was different from essential tremor. The foresight by Baughman in 1969 proved to be true in this patient. This case report provides new insights into the pathogenesis and treatment of tremor in Klinefelter’s syndrome, which would benefit patients who suffer from the tremor.

Keywords

Tremor Klinefelter’s syndrome Testosterone Motor neuron disturbance 

Notes

Acknowledgment

We thank ASKA Pharmaceutical Co., Ltd (Tokyo, Japan) for providing information about Enarmon depot®. There is no funding source.

Conflict of interest statement

The authors have no conflict of interest.

Supplementary material

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Supplementary material 1 (3GP 61 kb)
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Supplementary material 2 (3GP 53 kb)

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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Hiroyuki Kinoshita
    • 1
    Email author
  • Takuya Ohkubo
    • 1
    • 2
  • Masakazu Kaneko
    • 1
  • Nozomu Satoh
    • 2
  • Saneyuki Mizutani
    • 1
    • 2
  • Mutsuko Yasuda
    • 1
  • Akira Machida
    • 1
    • 2
  • Kinya Ishikawa
    • 2
  • Tomoyuki Kamata
    • 1
    • 2
  • Fumiatsu Yakushiji
    • 1
  1. 1.Department of Internal MedicineTokyo Metropolitan Bokutoh HospitalTokyoJapan
  2. 2.Department of Neurology and Neurological ScienceTokyo Medical and Dental University Graduate School of MedicineTokyoJapan

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