Journal of Neurology

, Volume 256, Issue 11, pp 1876–1880 | Cite as

Do patients having a decrease in SNAP amplitude during the course of MMN present with a different condition?

  • Emilien Delmont
  • Charles Benaïm
  • Mael Launay
  • Sabrina Sacconi
  • Marie-Hélène Soriani
  • Claude Desnuelle
Original Communication


A decrease in sensory nerve action potentials (SNAP) amplitude has been recently reported in some patients during the course of multifocal motor neuropathy with conduction blocks (MMNCB). It is not known if those patients have different clinical expression and disability when compared with typical MMNCB. Clinical, biological and electrophysiological assessments were performed in 15 patients fitting the diagnosis criteria of MMNCB, including normal SNAP amplitude at initial examination. Patients presenting with nerve entrapment or associated disease causative of sensory neuropathy were excluded. Median time of follow-up was 3 years (1–17 years). At the last examination, four patients had at least one SNAP amplitude below 50% of normal value. None had clinically objective sensory loss. Clinical and electrophysiological data obtained at the last examination were compared between patients with normal SNAP amplitude and patients with decreased SNAP amplitude. No difference between both population in term of age, sex, disease duration, anti-GM1 antibody titers, CSF data and number of conduction blocks was noted. In contrast, patients with decreased SNAP amplitude had worse overall neuropathy limitation scale (ONLS) scores (7 vs. 2; p = 0.02), a higher number of affected nerves (12.5 vs. 4; p = 0.018), a higher number of affected limb regions (6 vs. 2; p = 0.019) and lower median CMAP amplitude (2 mV vs. 6.5 mV; p = 0.04). They were all dependent on higher doses of IVIg (1.4 g/(kg 4 weeks vs. 0.6; p = 0.018). A reduction in SNAP amplitude during the course of MMNCB is associated with a more severe disease and a more prominent axonal loss. This result needs to be confirmed in a larger cohort.


Multifocal motor neuropathy with conduction block Axonal degeneration Lewis–Sumner syndrome Sensory nerve action potentials Intravenous immunoglobulin 



We thank Pr Said Beydoun for revision of the manuscript.


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Emilien Delmont
    • 1
  • Charles Benaïm
    • 1
  • Mael Launay
    • 1
  • Sabrina Sacconi
    • 1
  • Marie-Hélène Soriani
    • 1
  • Claude Desnuelle
    • 1
  1. 1.Centre de référence pour les Maladies NeuroMusculaires et la SLANice Cedex 3France

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