Journal of Neurology

, Volume 256, Issue 11, pp 1825–1831 | Cite as

Significant association of metabolic syndrome with silent brain infarction in elderly people

  • Hyung-Min Kwon
  • Beom Joon Kim
  • Jin-Ho Park
  • Wi-Sun Ryu
  • Chi-Kyung Kim
  • Su-Ho Lee
  • Sang-Bae Ko
  • Hyunwoo Nam
  • Seung-Hoon Lee
  • Yong-Seok Lee
  • Byung-Woo Yoon
Original Communication


A silent brain infarction (SBI) can predict clinical overt stroke or dementia. Studies focusing on the elderly population, where SBI is most common, are sparse. We examined the associations between SBI and metabolic syndrome (MetS) in healthy elderly individuals. Neurologically healthy subjects (1,254 persons, 723 males) aged ≥65 years who underwent brain MRI were evaluated. MetS was diagnosed following the AHA/NHLBI-2005 criteria. We examined associations between full syndrome (at least three of the five conditions) as well as its components and SBI while controlling for possible confounders. One hundred and ninety-seven subjects (15.7%) were found to have one or more SBIs on MRI. Age (1-year difference) was found to be significantly related to SBI prevalence (OR 1.09; 95% CI 1.05–1.12). MetS was significantly associated with SBI (OR 1.68; 95% CI 1.15–2.44). The component model of MetS showed a strong significance between elevated blood pressure (OR 1.89; 95% CI 1.23–2.91) and SBI. Subjects exhibiting more components of MetS showed more prevalent SBI and multiple SBIs. MetS was found to be significantly associated with SBI in neurologically healthy elderly people. The positive trend between the number of MetS components and SBI could be used as a diagnostic tool to predict and prevent future stroke.


Metabolic syndrome Silent brain infarction Aged MRI Cross-sectional study 



This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health and Welfare (A060171).


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Hyung-Min Kwon
    • 1
  • Beom Joon Kim
    • 2
  • Jin-Ho Park
    • 3
  • Wi-Sun Ryu
    • 2
  • Chi-Kyung Kim
    • 2
  • Su-Ho Lee
    • 2
  • Sang-Bae Ko
    • 2
  • Hyunwoo Nam
    • 1
  • Seung-Hoon Lee
    • 2
  • Yong-Seok Lee
    • 1
  • Byung-Woo Yoon
    • 2
  1. 1.Department of NeurologySeoul National University Boramae HospitalSeoulSouth Korea
  2. 2.Department of NeurologySeoul National University HospitalSeoulRepublic of Korea
  3. 3.Healthcare Research InstituteSeoul National University Hospital, Healthcare System Gangnam CenterSeoulSouth Korea

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