Journal of Neurology

, Volume 256, Issue 10, pp 1771–1772 | Cite as

Melanoma complicating treatment with Natalizumab (Tysabri) for multiple sclerosis

  • Azza Ismail
  • Julie Kemp
  • Basil SharrackEmail author
Letter to the Editors


Natalizumab (Tysabri, Biogen Idec and Elan Pharmaceuticals) is a humanized monoclonal antibody which targets the α4 subunits of the cellular adhesion molecules α4β1 and α4β7 integrins, blocking their interaction with their co-receptors VCAM-1, CS-1 and MadCAM-1 [3, 15]. This action reduces leukocyte trafficking into the brain and gut and mediates the beneficial effect of natalizumab in multiple sclerosis (MS) and Crohn’s disease [3]. The efficacy of natalizumab in patients with relapsing remitting MS was demonstrated in two phase III studies, AFFIRM and SENTINAL [10, 12]. These studies showed that when natalizumab was used as mono therapy or in combination with interferon beta-1a (Avonex) it significantly reduced relapse rate and slowed the progression of disability. Natalizumab was well tolerated with the most common adverse effects being headache, infusion reactions and a modest increase in urinary and respiratory tract infections [10, 12]. Neither trial identified any...


Melanoma Multiple Sclerosis Progressive Multifocal Leukoencephalopathy Natalizumab Progressive Multifocal Leukoencephalopathy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Conflict of interest statement



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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  1. 1.Department of NeurologyRoyal Hallamshire HospitalSheffieldUK

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