Advertisement

Journal of Neurology

, Volume 256, Issue 2, pp 287–288 | Cite as

Narcolepsy as an initial manifestation of neuromyelitis optica with antiaquaporin-4 antibody

  • T. Baba
  • I. Nakashima
  • T. Kanbayashi
  • M. Konno
  • T. Takahashi
  • K. Fujihara
  • T. Misu
  • A. Takeda
  • Y. Shiga
  • H. Ogawa
  • Y. Itoyama
LETTER TO THE EDITORS

Keywords

Excessive Daytime Sleepiness Narcolepsy Neuromyelitis Optica Multiple Sleep Latency Test Hypothalamic Lesion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Carlander B, Vincent T, Le Floch A, Pageot N, Camu W, Dauvilliers Y (2008) Hypocretinergic dysfunction in neuromyelitis optica with coma-like episodes. J Neurol Neurosurg Psychiatry 79:333–334PubMedCrossRefGoogle Scholar
  2. 2.
    Iseki K, Mezaki T, Oka Y, Terada K, Tomimoto H, Miki Y, Shibasaki H (2002) Hypersomnia in MS. Neurology 59:2006–2007PubMedGoogle Scholar
  3. 3.
    Kanbayashi T, Inoue Y, Chiba S, Aizawa R, Saito Y, Tsukamoto H, Fujii Y, Nishino S, Shimizu T (2002) CSF hypocretin- 1 (orexin-A) concentrations in narcolepsy with and without cataplexy and idiopathic hypersomnia. J Sleep Res 11:91–93PubMedCrossRefGoogle Scholar
  4. 4.
    Kato T, Kanbayashi T, Yamamoto K, Nakano T, Shimizu T, Hashimoto T, Ikeda S (2003) Hypersomnia and low CSF hypocretin-1 (orexin-A) concentration in a patient with multiple sclerosis showing bilateral hypothalamic lesions. Intern Med 42:743–745PubMedCrossRefGoogle Scholar
  5. 5.
    Lennon VA, Kryzer TJ, Pittock SJ, Verkman AS, Hinson SR (2005) IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. J Exp Med 202:473–477PubMedCrossRefGoogle Scholar
  6. 6.
    Marcus CL, Trescher WH, Halbower AC, Lutz J (2002) Secondary narcolepsy in children with brain tumors. Sleep 25:435–439PubMedGoogle Scholar
  7. 7.
    Nakashima I, Fujihara K, Miyazawa I, Misu T, Narikawa K, Nakamura M, Watanabe S, Takahashi T, Nishiyama S, Shiga Y, Sato S, Weinshenker BG, Itoyama Y (2006) Clinical and MRI features of Japanese patients with multiple sclerosis positive for NMOIgG. J Neurol Neurosurg Psychiatry 77:1073–1075PubMedCrossRefGoogle Scholar
  8. 8.
    Nozaki H, Shimohata T, Kanbayashi T, Sagawa Y, Katada SI, Satoh M, Onodera O, Tanaka K, Nishizawa M (2008) A patient with anti-aquaporin 4 antibody who presented with recurrent hypersomnia, reduced orexin (hypocretin) level, and symmetrical hypothalamic lesions. Sleep Med (in press)Google Scholar
  9. 9.
    Oka Y, Kanbayashi T, Mezaki T, Iseki K, Matsubayashi J, Murakami G, Matsui M, Shimizu T, Shibasaki H (2004) Low CSF hypocretin-1/orexin-A associated with hypersomnia secondary to hypothalamic lesion in a case of multiple sclerosis. J Neurol 251:885–886PubMedCrossRefGoogle Scholar
  10. 10.
    Pittock SJ, Lennon VA, Krecke K, Wingerchuk DM, Lucchinetti CF, Weinshenker BG (2006) Brain abnormalities in neuromyelitis optica. Arch Neurol 63:390–396PubMedCrossRefGoogle Scholar
  11. 11.
    Takahashi T, Fujihara K, Nakashima I, Misu T, Miyazawa I, Nakamura M, Watanabe S, Shiga Y, Kanaoka C, Fujimori J, Sato S, Itoyama Y (2007) Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO: a study on antibody titre. Brain 130:1235–1243PubMedCrossRefGoogle Scholar

Copyright information

© Steinkopff-Verlag 2009

Authors and Affiliations

  • T. Baba
    • 1
  • I. Nakashima
    • 1
  • T. Kanbayashi
    • 2
  • M. Konno
    • 1
  • T. Takahashi
    • 1
  • K. Fujihara
    • 1
  • T. Misu
    • 1
  • A. Takeda
    • 1
  • Y. Shiga
    • 1
  • H. Ogawa
    • 3
  • Y. Itoyama
    • 1
  1. 1.Dept. of NeurologyTohoku University School of MedicineSendaiJapan
  2. 2.Dept. of PsychiatryAkita University School of MedicineSendaiJapan
  3. 3.Dept. of Infectious and Respiratory, DiseasesTohoku University School of MedicineSendaiJapan

Personalised recommendations