Journal of Neurology

, Volume 255, Issue 9, pp 1290–1301 | Cite as

Migraine-associated risks and comorbidity

  • H. C. DienerEmail author
  • M. Küper
  • T. Kurth


This review reports important co-morbid conditions of migraine and resulting consequences for the choice of acute and preventive treatments of migraine. Comorbidity in this context means the occurrence of two diseases in an individual beyond chance. The basis of comorbidity can be genetic and/or based on common environmental factors. In some cases, the temporal relationship is unclear and one disease can cause another disease. In order to prove a real comorbidity, large-scale and wellperformed epidemiological studies are required.

Key words

stroke depression epilepsy coronary heart disease patent foramen ovale 


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© Springer 2008

Authors and Affiliations

  1. 1.Dept. of Neurology and Headache CenterUniversity Duisburg-EssenEssenGermany
  2. 2.Divisions of Aging and Preventive Medicine, Dept. of MedicineBrigham and Women’s Hospital, and Dept. of Epidemiology Harvard School of Public HealthBostonUSA

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