Journal of Neurology

, Volume 255, Issue 10, pp 1549–1554 | Cite as

Intravenous high-dose immunoglobulin treatment in recent onset childhood narcolepsy with cataplexy

  • Giuseppe Plazzi
  • Francesca Poli
  • Christian Franceschini
  • Antonia Parmeggiani
  • Piero Pirazzoli
  • Filippo Bernardi
  • Emmanuel Mignot
  • Alessandro Cicognani
  • Pasquale Montagna


We report on the outcome of intravenous high-dose immunoglobulin (IVIg) treatment in four children with narcolepsy and cataplexy, in whom the early diagnosis and the extreme disease severity were indications for this potentially efficacious therapy. One of four patients showed an objective and persistent improvement in clinical features during and after IVIg treatment. Our data partially support the recent report of the efficacy of IVIg treatment in early diagnosed narcolepsy with cataplexy and support the need for a controlled multicenter clinical trial on IVIg in narcolepsy.

Key words

narcolepsy with cataplexy intravenous immunoglobulins early treatment 


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Copyright information

© Springer 2008

Authors and Affiliations

  • Giuseppe Plazzi
    • 1
  • Francesca Poli
    • 1
  • Christian Franceschini
    • 1
  • Antonia Parmeggiani
    • 1
  • Piero Pirazzoli
    • 2
  • Filippo Bernardi
    • 2
  • Emmanuel Mignot
    • 3
  • Alessandro Cicognani
    • 2
  • Pasquale Montagna
    • 1
  1. 1.Sleep Disorders Center, Dept. of Neurological SciencesUniversity of BolognaBolognaItaly
  2. 2.Dept. of PediatricsUniversity of BolognaBolognaItaly
  3. 3.Center for NarcolepsyStanford UniversityCaliforniaUSA

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