Journal of Neurology

, Volume 255, Issue 9, pp 1344–1353

Brain SPECT in subtypes of mild cognitive impairment

Findings from the DESCRIPA multicenter study
  • Flavio Nobili
  • Giovanni B. Frisoni
  • Florence Portet
  • Frans Verhey
  • Guido Rodriguez
  • Anna Caroli
  • Jacques Touchon
  • Piero Calvini
  • Silvia Morbelli
  • Fabrizio De Carli
  • Ugo P. Guerra
  • Laura A. Van de Pol
  • Pieter-Jelle Visser
ORIGINAL COMMUNICATION

DOI: 10.1007/s00415-008-0897-4

Cite this article as:
Nobili, F., Frisoni, G.B., Portet, F. et al. J Neurol (2008) 255: 1344. doi:10.1007/s00415-008-0897-4

Abstract

The Development of Screening Guidelines and Clinical Criteria of Predementia Alzheimer’s Disease (DESCRIPA) multicenter study enrolled patients with MCI or subjective cognitive complaints (SUBJ), a part of whom underwent optional brain perfusion SPECT. These patients were classified as SUBJ (n = 23), nonamnestic MCI (naMCI; n = 17) and amnestic MCI (aMCI; n = 40) based on neuropsychology. Twenty healthy subjects formed the control (CTR) group. Volumetric regions of interest (VROI) analysis was performed in six associative cortical areas in each hemisphere. ANOVA for repeated measures, corrected for age and center, showed significant differences between groups (p = 0.01) and VROI (p < 0.0001) with a significant group-region interaction (p = 0.029). In the post hoc comparison, SUBJ did not differ from CTR. aMCI disclosed reduced uptake in the left hippocampus and bilateral temporal cortex (compared with CTR) or in the left hippocampus and bilateral parietal cortex (compared with SUBJ). In the naMCI group, reduced VROI values were found in the bilateral temporal cortex and right frontal cortex. In the comparison between aMCI and naMCI, the former had lower values in the left parietal cortex and precuneus. Discriminant analysis between SUBJ/CTR versus all MCI patients allowed correct allocations in 73 % of cases. Mean VROI values were highly correlated (p < 0.0001) with the learning measure of a verbal memory test, especially in the bilateral precunei and parietal cortex and in the left hippocampus. In a subset of 70 patients, mean VROI values showed a significant correlation (p < 0.05) with the white matter hyperintensities score on MRI. In conclusion, MCI subtypes have different perfusion patterns. The aMCI group exhibited a pattern that is typical of early Alzheimer’s disease, while the naMCI group showed a more anterior pattern of hypoperfusion. Instead, a homogeneous group effect was lacking in SUBJ.

Key words

subjective cognitive impairment amnestic MCI non-amnestic MCI brain SPECT verbal memory MRI 

Copyright information

© Springer 2008

Authors and Affiliations

  • Flavio Nobili
    • 1
  • Giovanni B. Frisoni
    • 2
  • Florence Portet
    • 3
  • Frans Verhey
    • 4
  • Guido Rodriguez
    • 1
  • Anna Caroli
    • 2
  • Jacques Touchon
    • 3
  • Piero Calvini
    • 5
  • Silvia Morbelli
    • 6
  • Fabrizio De Carli
    • 7
  • Ugo P. Guerra
    • 8
  • Laura A. Van de Pol
    • 9
  • Pieter-Jelle Visser
    • 4
    • 9
  1. 1.Clinical Neurophysiology Unit, Dept. of Endocrinological and Medical SciencesUniversity of GenoaGenoaItaly
  2. 2.IRCCS San Giovanni di Dio, Laboratory of Epidemiology and NeuroimagingBresciaItaly
  3. 3.Centre Memoire de Ressource et de Recherche, Service de NeurologieCHU Guy de ChauliacMontpellierFrance
  4. 4.Dept. of Psychiatry and NeuropsychologyUniversity of MaastrichtMaastrichtThe Netherlands
  5. 5.Dept. of Physics and INFNUniversity of GenoaGenoaItaly
  6. 6.Nuclear Medicine Unit, Dept. of Internal MedicineUniversity of GenoaGenoaItaly
  7. 7.Institute of Molecular Bioimaging and PhysiologyNational Research CouncilGenoaItaly
  8. 8.Nuclear Medicine UnitOspedali Riuniti of BergamoBergamoItaly
  9. 9.Dept. of NeurologyVU University Medical CentreAmsterdamThe Netherlands

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