Journal of Neurology

, Volume 255, Issue 4, pp 561–566 | Cite as

Cortical thickness abnormality in juvenile myoclonic epilepsy

  • W. S. Tae
  • S. H. Kim
  • E. Y. Joo
  • S. J. Han
  • I. Y. Kim
  • S. I. Kim
  • J.-M. Lee
  • S. B. Hong


Previous studies on gray matter concentration changes in patients with juvenile myoclonic epilepsy (JME) are inconsistent. To investigate cortical abnormality in JME differently, we measured the cortical thickness in 19 JME patients and 18 normal controls. Results showed that the cortical thicknesses of superior/middle/medial frontal gyri, and superior/middle/ inferior temporal gyri were decreased in JME patients. Moreover, cortical thicknesses of precentral gyrus and medial orbital gyrus of right hemispheres were negatively correlated with disease duration. These findings suggest that JME brains have cortical gray matter atrophy in the frontal and temporal lobes.

Key words

juvenile myoclonic epilepsy magnetic resonance imaging gray matter cortical thickness epilepsy 


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Copyright information

© Steinkopff-Verlag 2008

Authors and Affiliations

  • W. S. Tae
    • 1
    • 2
  • S. H. Kim
    • 2
  • E. Y. Joo
    • 1
  • S. J. Han
    • 3
  • I. Y. Kim
    • 2
  • S. I. Kim
    • 2
  • J.-M. Lee
    • 2
  • S. B. Hong
    • 1
  1. 1.Dept. of Neurology, Samsung Medical CenterSungkyunkwan University School of MedicineSeoulSouth Korea
  2. 2.Dept. of Biomedical EngineeringHanyang University, SungdongSeoulSouth Korea
  3. 3.Dept. of NeurologyInam Neuroscience Research Center College of Medicine Wonkwang UniversityGyeonggi-doKorea

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