Journal of Neurology

, 255:828 | Cite as

Incidence of central nervous system involvement in chronic lymphocytic leukemia and outcome to treatment

  • M. C. J. Hanse
  • M. B. van’t Veer
  • K. van Lom
  • M. J. van den Bent
ORIGINAL COMMUNICATION

Abstract

Leptomeningeal involvement in patients with CLL is relatively rare and the prognosis is usually considered to be poor. The authors reviewed all CLL patients treated in a tertiary referral center to assess the incidence and outcome of leptomeningeal involvement (LI) in CLL. They found an incidence of 1–2% of LI. Most of the patients with LI had a longterm survival, despite failure to clear the cerebrospinal fluid from tumor cells.

Key words

CLL leptomeningeal involvement 

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Copyright information

© Steinkopff-Verlag 2008

Authors and Affiliations

  • M. C. J. Hanse
    • 1
  • M. B. van’t Veer
    • 2
  • K. van Lom
    • 2
  • M. J. van den Bent
    • 1
  1. 1.Dept. of Neuro-OncologyDaniel den Hoed Cancer CenterRotterdamThe Netherlands
  2. 2.Dept. of HematologyDaniel den Hoed Cancer CenterRotterdamThe Netherlands

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