Journal of Neurology

, 255:828 | Cite as

Incidence of central nervous system involvement in chronic lymphocytic leukemia and outcome to treatment

  • M. C. J. Hanse
  • M. B. van’t Veer
  • K. van Lom
  • M. J. van den Bent


Leptomeningeal involvement in patients with CLL is relatively rare and the prognosis is usually considered to be poor. The authors reviewed all CLL patients treated in a tertiary referral center to assess the incidence and outcome of leptomeningeal involvement (LI) in CLL. They found an incidence of 1–2% of LI. Most of the patients with LI had a longterm survival, despite failure to clear the cerebrospinal fluid from tumor cells.

Key words

CLL leptomeningeal involvement 


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Copyright information

© Steinkopff-Verlag 2008

Authors and Affiliations

  • M. C. J. Hanse
    • 1
  • M. B. van’t Veer
    • 2
  • K. van Lom
    • 2
  • M. J. van den Bent
    • 1
  1. 1.Dept. of Neuro-OncologyDaniel den Hoed Cancer CenterRotterdamThe Netherlands
  2. 2.Dept. of HematologyDaniel den Hoed Cancer CenterRotterdamThe Netherlands

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