Journal of Neurology

, Volume 255, Issue 10, pp 1449–1463 | Cite as

Basic and escalating immunomodulatory treatments in multiple sclerosis: Current therapeutic recommendations

  • Multiple Sclerosis Therapy Consensus Group (MSTCG)
  • H. WiendlEmail author
  • K. V. ToykaEmail author
  • P. Rieckmann
  • R. Gold
  • H.-P. Hartung
  • R. Hohlfeld


This review updates and extends earlier Consensus Reports related to current basic and escalating immunomodulatory treatments in multiple sclerosis (MS). The recent literature has been extracted for new evidence from randomized controlled trials, open treatment studies and reported expert opinion, both in original articles and reviews, and evaluates indications and safety issues based on published data. After data extraction from published full length publications and critically weighing the evidence and potential impact of the data, the review has been drafted and circulated within the National MS Societies and the European MS Platform to reach consensus within a very large group of European experts, combining evidence-based criteria and expert opinion where evidence is still incomplete. The review also outlines a few areas of controversy and delineates the need for future research.

Key words

Multiple Sclerosis immunotherapy randomized trials monoclonal antibodies interferon β glatirameracetate treatment escalation 


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© Springer 2008

Authors and Affiliations

  • Multiple Sclerosis Therapy Consensus Group (MSTCG)
  • H. Wiendl
    • 1
    Email author
  • K. V. Toyka
    • 1
    Email author
  • P. Rieckmann
    • 1
  • R. Gold
    • 1
  • H.-P. Hartung
    • 1
  • R. Hohlfeld
    • 1
  1. 1.Dept. of Neurology and Clinical Research, Unit for MS and NeuroimmunologyUniversity of WürzburgWürzburgGermany

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