Journal of Neurology

, Volume 254, Supplement 2, pp II18–II21 | Cite as

Cognitive dysfunctions in multiple sclerosis – a “multiple disconnection syndrome”?

  • Pasquale Calabrese
  • Iris Katharina Penner


After giving a brief overview of the cognitive core deficit in multiple sclerosis (MS), pros and cons of considering the clinical characteristics as a form of ‘subcortical dementia’ are discussed. By comparing the neuropsychological descriptions of MS patients as given in the literature to other neurological diseases which are also associated with neuropsychological deficiencies, we propose the term ‘multiple disconnection syndrome’ to describe the variety of neuropsychological deficits encountered in MS.

Key words

multiple sclerosis neuropsychology cognition disconnection syndrome 


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Copyright information

© Steinkopff-Verlag 2007

Authors and Affiliations

  1. 1.Dept. of neuropsychology and behavioural neurologyUniversity Clinic of NeurologyBochum-LangendreerGermany
  2. 2.Dept. of Cognitive neuroscienceUniversity of BaselSwitzerland
  3. 3.Dept. of Neuropsychology and behavioral neurologyRuhr-University BochumBochumGermany

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