Multiple sclerosis therapy: An update on recently finished trials

Journal of Neurology volume 254, pages 1473–1490 (2007)Cite this article

Abstract

Six pharmacological agents are currently approved for the treatment of multiple sclerosis (MS).However, all established substances are only partially effective in reducing disease progression or relapse rates. In addition, they have potentially serious side effects. Thus, significant efforts are being made to develop new agents or to optimize current therapies. The latter includes modifications of dose, route of administration or the time point of treatment initiation. In this review, we provide an update on the most important clinical phase II/III trials on approved and novel immunotherapeutic strategies in MS reported during the last two years. Pharmacotherapies include agents that target chemoattraction, cell migration, chemotherapies, and antigen-based therapies.

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Affiliations

  1. Dept. of Neurology, Bayerische Julius-Maximilians-Universität Würzburg, Josef-Schneider-Str. 11, 97080, Würzburg, Germany

    C. Kleinschnitz MD, S. G. Meuth MD, PhD & H. Wiendl MD

  2. University of Düsseldorf, Dept. of Neurology, Düsseldorf, Germany

    B. Kieseier MD, PhD

  3. University of Texas, Dept. of Neurology, Southwestern Medical Center at Dallas, TX, U.S.A.

    O. Stüve MD

  4. Neurology Section, VA North Texas Health Care System, Medical Service, Dallas

    O. Stüve MD

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  1. C. Kleinschnitz MD
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  2. S. G. Meuth MD, PhD
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  3. O. Stüve MD
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  4. B. Kieseier MD, PhD
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  5. H. Wiendl MD
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Correspondence to H. Wiendl MD.

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Kleinschnitz, C., Meuth, S.G., Stüve, O. et al. Multiple sclerosis therapy: An update on recently finished trials. J Neurol 254, 1473–1490 (2007). https://doi.org/10.1007/s00415-007-0684-7

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Key words

  • multiple sclerosis
  • therapy
  • disease modifying drugs
  • trials
  • natalizumab