Journal of Neurology

, Volume 254, Issue 3, pp 398–399 | Cite as

Polymorphisms in the neuromyelitis optica auto-antigen AQP4 and susceptibility to multiple sclerosis

  • Maria Ban
  • Amie Walton
  • An Goris
  • Julia Gray
  • Alastair Compston
  • Stephen Sawcer
LETTER TO THE EDITORS

Keywords

Multiple Sclerosis genetics AQP4 susceptibility 

Notes

Acknowledgements

We thank members of the Association of British Neurologists for notifying families. This work was supported by the Wellcome Trust (grant 057097), the Multiple Sclerosis Society of the United States (grant RG3500-A-1), the Multiple Sclerosis Society of Great Britain and Ireland (grant 730/02) and the National Institute of Health (NS 049477-01A1). AG is a Postdoctoral Fellow of the Research Foundation – Flanders (FWO – Vlaanderen).

References

  1. 1.
    Aoki-Yoshino K, Uchihara T, Duyckaerts C, Nakamura A, Hauw JJ, Wakayama Y (2005) Enhanced expression of aquaporin 4 in human brain with inflammatory diseases. Acta Neuropathol (Berl) 110:281–288CrossRefGoogle Scholar
  2. 2.
    Compston A (2004) ‘The marvellous harmony of the nervous parts’: the origins of multiple sclerosis. Clin Med 4:346(354PubMedGoogle Scholar
  3. 3.
    Compston A, Coles A (2002) Multiple sclerosis. Lancet 359:1221–1231PubMedCrossRefGoogle Scholar
  4. 4.
    Dudbridge F (2003) Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 25:115–121PubMedCrossRefGoogle Scholar
  5. 5.
    Johnson GC, Esposito L, Barratt BJ, Smith AN, Heward J, Di Genova G, Ueda H, Cordell HJ, Eaves IA, Dudbridge F, Twells RC, Payne F, Hughes W, Nutland S, Stevens H, Carr P, Tuomilehto-Wolf E, Tuomilehto J, Gough SC, Clayton DG, Todd JA (2001) Haplotype tagging for the identification of common disease genes. Nat Genet 29:233–237PubMedCrossRefGoogle Scholar
  6. 6.
    Jung JS, Bhat RV, Preston GM, Guggino WB, Baraban JM, Agre P (1994) Molecular characterization of an aquaporin cDNA from brain: candidate osmoreceptor and regulator of water balance. Proc Natl Acad Sci USA 91:13052–13056PubMedCrossRefGoogle Scholar
  7. 7.
    Lennon VA, Kryzer TJ, Pittock SJ, Verkman AS, Hinson SR (2005) IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. J Exp Med 202:473–477PubMedCrossRefGoogle Scholar
  8. 8.
    Lennon VA, Wingerchuk DM, Kryzer TJ, Pittock SJ, Lucchinetti CF, Fujihara K, Nakashima I, Weinshenker BG (2004) A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis. Lancet 364:2106–2112PubMedCrossRefGoogle Scholar
  9. 9.
    Weinshenker BG (2003) Neuromyelitis optica: what it is and what it might be. Lancet 361:889–890PubMedCrossRefGoogle Scholar
  10. 10.
    Weinshenker BG, Wingerchuk DM, Nakashima I, Fujihara K, Lennon VA (2006) OSMS is NMO, but not MS: proven clinically and pathologically. Lancet Neurol 5:110–111PubMedCrossRefGoogle Scholar

Copyright information

© Steinkopff Verlag Darmstadt 2007

Authors and Affiliations

  • Maria Ban
    • 1
  • Amie Walton
    • 1
  • An Goris
    • 1
    • 2
  • Julia Gray
    • 1
  • Alastair Compston
    • 1
  • Stephen Sawcer
    • 1
  1. 1.Dept. of Clinical NeurosciencesUniversity of Cambridge, Addenbrooke’s HospitalCambridgeUK
  2. 2.Laboratory of Neuroimmunology, Section of Experimental NeurologyKatholieke Universiteit LeuvenLeuvenBelgium

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