Journal of Neurology

, Volume 254, Issue 2, pp 255–256 | Cite as

Leber’s Hereditary Optic Neuropathy associated with cocaine, ecstasy and telithromycin consumption

  • Elena Cardaioli
  • Paola Da Pozzo
  • Gian Nicola Gallus
  • Rossella Franceschini
  • Alessandra Rufa
  • Maria Teresa Dotti
  • Aldo Caporossi
  • Antonio Federico
LETTER TO THE EDITORS

Keywords

Cocaine Ecstasy Telithromycin Increase Reactive Oxygen Species Production Retinal Ganglion Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

Research was partly supported by a grant from University of Siena and Regione Toscana to AF.

References

  1. 1.
    Newman NJ (2005) Hereditary optic neuropathies: from the mitochondria to the optic nerve. Am J Ophthalmol 140:517–523PubMedGoogle Scholar
  2. 2.
    Howell N (1998) Leber hereditary optic neuropathy: respiratory chain dysfunction and degeneration of the optic nerve. Vision Res 38:1495–1504PubMedCrossRefGoogle Scholar
  3. 3.
    Battisti C, Formichi P, Cardaioli E, et al. (2004) Cell response to oxidative stress induced apoptosis in patients with Leber’s hereditary optic neuropathy. J Neurol Neurosurg Psychiatry 75:1731–1736PubMedCrossRefGoogle Scholar
  4. 4.
    Zanna C, Ghelli A, Porcelli AM, Martinuzzi A, Carelli V, Rugolo M (2005) Caspase-independent death of Leber’s hereditary optic neuropathy cybrids is driven by energetic failure and mediated by AIF and Endonuclease G. Apoptosis 10:997–1007PubMedCrossRefGoogle Scholar
  5. 5.
    Hudson G, Keers S, Yu Wai Man P, et al. (2005) Identification of an X_chromosomal locus and haplotype modulating the phenotype of a mitochondrial DNA disorder. Am J Hum Genet 77:1086–1091PubMedCrossRefGoogle Scholar
  6. 6.
    Shaikh S, Ta C, Basham AA, Mansour S (2001) Leber hereditary optic neuropathy associated with antiretroviral therapy for human immunodeficiency virus infection. Am J Ophthalmol 131:143–145PubMedCrossRefGoogle Scholar
  7. 7.
    Rufa A, Dotti MT, Cardaioli E, Da Pozzo P, Federico A (2005) Leber hereditary optic neuropathy in 2 of 4 siblings with 11778 mtDNA mutation: clinical variability or effect of toxic environmental exposure? Eur Neurol 53:32–4 [Published Online First: 10 February 2005]PubMedCrossRefGoogle Scholar
  8. 8.
    Kovacic P (2005) Role of oxidative metabolites of cocaine in toxicity and addiction: oxidative stress and electron transfer. Med Hypotheses 64:350–356PubMedCrossRefGoogle Scholar
  9. 9.
    Zaragoza A, Diez-Fernandez C, Alvarez AM, Andres D, Cascales M (2001) Mitochondrial involvement in cocaine-treated rat hepatocytes: effect of N-acetylcysteine and deferoxamine. Br J Pharmacol 132:1063–1070PubMedCrossRefGoogle Scholar
  10. 10.
    Fosslien E (2001) Mitochondrial medicine–molecular pathology of defective oxidative phosphorylation. Ann Clin Lab Sci 31:25–67PubMedGoogle Scholar
  11. 11.
    Dietrich JB, Poirier R, Aunis D, Zwiller J (2004) Cocaine downregulates the expression of the mitochondrial genome in rat brain. Ann N Y Acad Sci 1025:345–350PubMedCrossRefGoogle Scholar
  12. 12.
    Deng X, Cadet JL (1999) Methamphetamine administration causes overexpression of nNOS in the mouse striatum. Brain Res 851:254–257PubMedCrossRefGoogle Scholar
  13. 13.
    Jimenez A, Jorda EG, Verdaguer E, et al. (2004) Neurotoxicity of amphetamine derivatives is mediated by caspase pathway activation in rat cerebellar granule cells. Toxicol Appl Pharmacol 196:223–234PubMedCrossRefGoogle Scholar
  14. 14.
    Burrows KB, Nixdorf WL, Yamamoto BK (2000) Central administration of methamphetamine synergizes with metabolic inhibition to deplete striatal monoamines. J Pharmacol Exp Ther 292(3):853–860PubMedGoogle Scholar
  15. 15.
    Beretta S, Mattavelli L, Sala G, et al. (2004) Leber hereditary optic neuropathy mtDNA mutations disrupt glutamate transport in cybrid cell lines. Brain 127(Pt 10):2183–92 [Published Online First: 1 September 2004]PubMedCrossRefGoogle Scholar
  16. 16.
    Clay KD, Hanson JS, Pope SD, Rissmiller RW, Purdum PP 3rd, Banks PM (2006) Brief Communication: Severe Hepatotoxicity of Telithromycin: Three Case Reports and Literature Review. Ann Intern Med [Epub ahead of print]Google Scholar

Copyright information

© Steinkopff Verlag Darmstadt 2007

Authors and Affiliations

  • Elena Cardaioli
    • 1
    • 2
  • Paola Da Pozzo
    • 1
  • Gian Nicola Gallus
    • 1
  • Rossella Franceschini
    • 3
  • Alessandra Rufa
    • 1
  • Maria Teresa Dotti
    • 1
  • Aldo Caporossi
    • 3
  • Antonio Federico
    • 1
  1. 1.Dept. of Neurological and Behavioural SciencesMedical School, University of SienaSienaItaly
  2. 2.Research position supported by Associazione Anni VerdiRomeItaly
  3. 3.Dept. of Ophthalmological and Neurosurgical SciencesUniversity of SienaSienaItaly

Personalised recommendations