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Journal of Neurology

, Volume 253, Issue 12, pp 1533–1541 | Cite as

News on the genetics, epidemiology, medical care and translational research of Schwannomas

  • C.O. Hanemann
  • D.G. Evans
REVIEW

Abstract

Recent years have seen substantial news and updates in the genetics and diagnosis of schwannomas, even a new hereditary disease with schwannomas; Schwannomatosis has been defined. These developments have consequently led to better evaluation of the incidence of schwannomas. Although there has also been progress in the treatment of schwannomas especially in the field of radiation therapy, hereditary diseases with multiple tumours still represent a therapeutic dilemma. NF2 in particular still causes major morbidity and mortality owing to the neurological deficit of multiple tumour disease and deafness caused by vestibular nerve involvement. Thus there has been great enthusiasm about disease models in the hope that translational research will give rise to new therapies.

Keywords

Schwannomas Neurofibromatosis 2 Schwannomatosis translational research review 

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Copyright information

© Steinkopff Verlag Darmstadt 2006

Authors and Affiliations

  1. 1.Clinical NeurobiologyInst. Biomedical and Clinical Science, Peninsula Medical SchoolPlymouthUK
  2. 2.Academic Unit of Medical GeneticsSt Mary’s HospitalManchesterUK

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