Journal of Neurology

, 254:722 | Cite as

Topographic brain mapping of the international cooperative ataxia rating scale

A positron emission tomography study
  • Po-Shan Wang
  • Ren-Shyan Liu
  • Bang-Hung Yang
  • Bing-Wen Soong


The International Cooperative Ataxia Rating Scale (ICARS) is a 100-point semiquantitative scale designed primarily to assess cerebellar dysfunction. However, little is known of the metric properties of this scale. We assessed the ICARS by rating the severity of cerebellar dysfunction in 27 patients with spinocerebellar ataxias (SCA), three patients with sporadic olivopontocerebellar ataxia and 24 healthy control subjects. [18F]-fluorodeoxyglucose (FDG) positron emission tomography (PET) study was also performed on each subject. The statistical parametric mapping analyses revealed a significant correlation between the ICARS scores and functional impairment of the frontal regions within SCA patients. The glucose metabolism in the cerebellum, thalamus and caudate nucleus had significant differences between SCA patients and healthy control subjects. The results suggested that the clinical severity of SCA patients correlated with the functional impairment in the frontal regions, the targets of cerebellar efferent projections.

Key words

positron emission tomography spinocerebellar ataxias ICARS 


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Copyright information

© Steinkopff-Verlag 2007

Authors and Affiliations

  • Po-Shan Wang
    • 1
    • 2
    • 3
  • Ren-Shyan Liu
    • 4
  • Bang-Hung Yang
    • 4
  • Bing-Wen Soong
    • 1
    • 2
  1. 1.The Neurological InstituteTaipei Veterans General HospitalTaipeiTaiwan 11217
  2. 2.Dept. of NeurologyNational Yang-Ming University School of MedicineTaipeiTaiwan
  3. 3.Dept. of NeurologyTaipei Municipal Gan-Dau HospitalTaipeiTaiwan
  4. 4.Dept. of Nuclear Medicine, National PET/Cyclotron CenterTaipei Veterans General HospitalTaipeiTaiwan

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