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Journal of Neurology

, Volume 253, Issue 10, pp 1362–1364 | Cite as

Long-term improvement of paroxysmal dystonic choreathetosis with acetazolamide

  • Veronique Michel
  • Florence Riant
  • Elisabeth Tournier-Lasserve
  • Dominique Guehl
  • Alain Lagueny
  • Bernard Bioulac
  • Pierre BurbaudEmail author
LETTER TO THE EDITORS

Sirs: Paroxysmal dyskinesias are a heterogeneous group of movement disorders characterized by recurrent brief episodes of abnormal involuntary movements [1, 2, 3] Among them, paroxysmal dystonic choreoathetosis (PDC) is associated with dystonic or choreic attacks unrelated to movement. It may occur spontaneously at rest without any triggering factors but attacks are frequently precipitated by caffeine or alcohol consumption, stress and fatigue. In contrast to paroxysmal kinesigenic choreathetosis (PKC), PDC attacks are more dystonic, usually last longer, and are less frequent with long attack-free intervals [3, 4]. Although most cases are familial, sporadic and secondary forms of PDC have been reported [4, 5].

We report a patient with a sporadic severe PDC which has been dramatically improved by acetazolamide over a period of three years. This 17-year-old boy who had a normal birth and no familial history developed his first symptoms at the age of 12. He presented recurrent episodes of...

Keywords

Dystonia Acetazolamide Valproate Sodium Tiapride Paroxysmal Kinesigenic Dyskinesia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Steinkopff Verlag Darmstadt 2006

Authors and Affiliations

  • Veronique Michel
    • 1
  • Florence Riant
    • 2
  • Elisabeth Tournier-Lasserve
    • 2
  • Dominique Guehl
    • 1
  • Alain Lagueny
    • 3
  • Bernard Bioulac
    • 1
  • Pierre Burbaud
    • 1
    Email author
  1. 1.Service de Neurophysiologie cliniqueHopital PellegrinLéonFrance
  2. 2.INSERM EPI-99-21, Hôpital LariboisièreParisFrance
  3. 3.Service de Neurologie, Hopital Haut-LévèquePessacFrance

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