Long-term improvement of paroxysmal dystonic choreathetosis with acetazolamide
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Sirs: Paroxysmal dyskinesias are a heterogeneous group of movement disorders characterized by recurrent brief episodes of abnormal involuntary movements [1, 2, 3] Among them, paroxysmal dystonic choreoathetosis (PDC) is associated with dystonic or choreic attacks unrelated to movement. It may occur spontaneously at rest without any triggering factors but attacks are frequently precipitated by caffeine or alcohol consumption, stress and fatigue. In contrast to paroxysmal kinesigenic choreathetosis (PKC), PDC attacks are more dystonic, usually last longer, and are less frequent with long attack-free intervals [3, 4]. Although most cases are familial, sporadic and secondary forms of PDC have been reported [4, 5].
We report a patient with a sporadic severe PDC which has been dramatically improved by acetazolamide over a period of three years. This 17-year-old boy who had a normal birth and no familial history developed his first symptoms at the age of 12. He presented recurrent episodes of...
KeywordsDystonia Acetazolamide Valproate Sodium Tiapride Paroxysmal Kinesigenic Dyskinesia
- 3.Bathia KP (2001) Familial (idiopathic) paroxysmal dyskinesias:an update. Sem Neurol 21:68–74Google Scholar
- 4.Bressman SB, Fahn S, Burke RE. Paroxysmal non-kinesigenic dystonia. Advances in Neurology, vol. 50, pp403–13:dystonia 2, ed. by Stanley Fahn et al., Raven Press, New York 1988 Google Scholar
- 13.Tournier-Lasserre E (1999) CACNA1A mutations:hemiplegic migraine, episodic ataxia type 2, and the others. Neurology 53(1):3–4Google Scholar
- 17.Fouad GT, Rainer S, Wilkowski J, et al. (2003) A gene for familial paroxysmal dyskinesia (FPD1) maps to chromosome 2q. Am J Hum Genet, 1996, 59:135–139.Cytogenet Genome Res 100(1–4):147–53Google Scholar