Journal of Neurology

, Volume 253, Issue 9, pp 1203–1209 | Cite as

Contrast sensitivity, first-order motion and Initial ocular following in demyelinating optic neuropathy

  • Janet C. Rucker
  • Boris M. Sheliga
  • Edmond J. FitzGibbon
  • Frederick A. Miles
  • R. John Leigh
ORIGINAL COMMUNICATION

Abstract

The ocular following response (OFR) is a measure of motion vision elicited at ultra-short latencies by sudden movement of a large visual stimulus. We compared the OFR to vertical sinusoidal gratings (spatial frequency 0.153 cycles/° or 0.458 cycles/°) of each eye in a subject with evidence of left optic nerve demyelination due to multiple sclerosis (MS). The subject showed substantial differences in vision measured with stationary low-contrast Sloan letters (20/63 OD and 20/200 OS at 2.5% contrast) and the Lanthony Desaturated 15-hue color test (Color Confusion Index 1.11 OD and 2.14 OS). Compared with controls, all of the subject’s OFR to increasing contrast showed a higher threshold. The OFR of each of the subject’s eyes were similar for the 0.153 cycles/° stimulus, and psychophysical measurements of his ability to detect these moving gratings were also similar for each eye. However, with the 0.458 cycles/° stimulus, the subject’s OFR was asymmetric and the affected eye showed decreased responses (smaller slope constant as estimated by the Naka-Rushton equation). These results suggest that, in this case, optic neuritis caused a selective deficit that affected parvocellular pathways mediating higher spatial frequencies, lower-contrast, and color vision, but spared the field-holding mechanism underlying the OFR to lower spatial frequencies. The OFR may provide a useful method to study motion vision in individuals with disorders affecting anterior visual pathways.

Keywords

optic neuritis multiple sclerosis saccades pursuit 

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Copyright information

© Steinkopff Verlag Darmstadt 2006

Authors and Affiliations

  • Janet C. Rucker
    • 2
    • 3
  • Boris M. Sheliga
    • 1
  • Edmond J. FitzGibbon
    • 1
  • Frederick A. Miles
    • 1
  • R. John Leigh
    • 2
    • 3
    • 4
  1. 1.Laboratory of Sensorimotor Research, National Eye InstituteNational Institutes of HealthBethesdaUSA
  2. 2.Veterans Affairs Medical CenterCleveland
  3. 3.University HospitalsCase Western Reserve UniversityCleveland
  4. 4.Department of NeurologyUniversity HospitalsClevelandUSA

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