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Journal of Neurology

, Volume 253, Issue 12, pp 1642–1643 | Cite as

Amyotrophic lateral sclerosis in an urban setting

A population based study of inner city London
  • Clare A. Johnston
  • Biba R. Stanton
  • Martin R. Turner
  • Rebecca Gray
  • Ashley Hay-Ming Blunt
  • David Butt
  • Mary-Ann Ampong
  • Christopher E. Shaw
  • P. Nigel Leigh
  • Ammar Al-Chalabi
LETTER TO THE EDITORS

Sirs: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease primarily affecting cortical and spinal motor neurons. There have been several previous population studies, reporting incidences between 0.44 and 3.2 per 100,000 person-years[1, 2].

As a preliminary step in establishing a population register for ALS in South-East England, we have identified all prevalent cases in the London Boroughs of Lambeth, Southwark and Lewisham (LSL) between 1 January 1997 and 31 July 2004. Cases were identified from multiple sources to ensure ascertainment was as complete as possible, but it is important to recognise that this register covers a relatively small population, with a high rate of migration in and out of the area.

Seventy-three individuals with ALS were identified, of whom 56 were newly diagnosed (23 female, 33 male). Crude incidence was 1.20 per 100,000 person-years and prevalence 4.06 per 100,000 (Table  1). For England and Wales, the projected age-adjusted incidence rate was...

Keywords

Amyotrophic Lateral Sclerosis Lifetime Risk African Ancestry Spinal Motor Neuron Crude Incidence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

We thank Drs. Bryan Traynor and Orla Hardiman who kindly provided data from the Irish ALS register, and Miss Rosie Leigh for her contribution to the data collection. We are grateful to the MRC, MNDA, Jenkins family and Myrtle Sketchley Memorial Trust for funding.

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Copyright information

© Steinkopff Verlag Darmstadt 2006

Authors and Affiliations

  • Clare A. Johnston
    • 1
  • Biba R. Stanton
    • 1
    • 2
  • Martin R. Turner
    • 1
  • Rebecca Gray
    • 1
  • Ashley Hay-Ming Blunt
    • 1
  • David Butt
    • 1
  • Mary-Ann Ampong
    • 2
  • Christopher E. Shaw
    • 1
    • 2
  • P. Nigel Leigh
    • 1
    • 2
  • Ammar Al-Chalabi
    • 1
    • 2
    • 3
  1. 1.MRC Centre for Neurodegeneration ResearchKing’s College London, Institute of PsychiatryLondon
  2. 2.King’s College Hospital NHS Trust London
  3. 3.Institute of Psychiatry PO43London

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