Journal of Neurology

, Volume 253, Issue 3, pp 275–279

Neurophysiological evidence of corticospinal tract abnormality in patients with Parkin mutations

  • A. De Rosa
  • G. Volpe
  • L. Marcantonio
  • L. Santoro
  • A. Brice
  • A. Filla
  • A. Perretti
  • G. De Michele
REVIEW

DOI: 10.1007/s00415-006-0096-0

Cite this article as:
De Rosa, A., Volpe, G., Marcantonio, L. et al. J Neurol (2006) 253: 275. doi:10.1007/s00415-006-0096-0

Abstract

Mutations in the parkin gene (PARK2) are the most frequent cause of autosomal recessive early–onset Parkinson disease. We performed a transcranial magnetic stimulation study in four patients with parkin mutations. Two patients had a prolonged central motor conduction time at both upper and lower limb, one only at the arm and one only at the leg. The MEP threshold was increased in one patient for the arm and in two for the leg. The MEP amplitude was reduced in one and central silent period shortened in two. The findings demonstrate corticospinal dysfunction in these patients and suggest that the extent of central nervous system involvement in parkin disease may be wider that hitherto supposed.

Key words

corticospinal pathway TMS MEP Parkinson disease parkin mutation 

Copyright information

© Steinkopff-Verlag 2006

Authors and Affiliations

  • A. De Rosa
    • 1
  • G. Volpe
    • 1
  • L. Marcantonio
    • 1
  • L. Santoro
    • 1
  • A. Brice
    • 2
  • A. Filla
    • 1
  • A. Perretti
    • 1
  • G. De Michele
    • 1
  1. 1.Dipartimento di Scienze Neurologiche Università degli Studi di Napoli Federico IINapoliItaly
  2. 2.INSERM U289, Department of Genetics, Cytogenetics and EmbryologyPitiè-Salpêtrière HospitalParisFrance

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