Journal of Neurology

, Volume 253, Issue 5, pp 636–639 | Cite as

Multiple sclerosis and autoimmune diseases

Epidemiology and HLA–DR association in North–east Italy
  • A. Laroni
  • M. Calabrese
  • P. Perini
  • M. P. Albergoni
  • F. Ranzato
  • M. Tiberio
  • L. Battistin
  • P. Gallo
ORIGINAL COMMUNICATION

Abstract

An autoimmune background is thought to characterize the families of multiple sclerosis (MS) patients, but disease patterns and HLA–DR association seem to vary considerably among different ethnic groups. We investigated the prevalence of autoimmune diseases in 245 MS patients and 245 age– and sex–matched normal controls (NC), originating from and living in North–east Italy, and their first degree relatives, using a case–control method. Further, HLA–DRB1 expression was analysed in MS and NC. The following significant findings were observed: 1) a significant excess of autoimmunity in firstdegree relatives of MS patients (p = 0.000), 2) an association of MS with Type 1 diabetes mellitus (T1DM) (p = 0.02), 3) an increase in DR4 expression (namely DRB1*0401) in MS patients from families with multiple autoimmune pathology compared with reference MS patients (p=0.02) and NC (p=0.01).We conclude that the risk of autoimmune disease is higher in first–degree relatives of MS patients and that disease association and HLA–DR expression in North–east Italy differs from other geographic regions of Europe.

Key words

multiple sclerosis autoimmune disease epidemiology HLA–DR 

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Copyright information

© Steinkopff-Verlag 2006

Authors and Affiliations

  • A. Laroni
    • 3
  • M. Calabrese
    • 3
  • P. Perini
    • 3
  • M. P. Albergoni
    • 1
  • F. Ranzato
    • 3
  • M. Tiberio
    • 3
  • L. Battistin
    • 2
    • 3
  • P. Gallo
    • 3
  1. 1.Blood and Tissue BankUniversity Hospital of PadovaPadovaItaly
  2. 2.IRCCS San CamilloVenice LidoItaly
  3. 3.Multiple Sclerosis Centre of the Veneto, Region, First Neurology Clinic—Dept. of NeurosciencesUniversity of PadovaPadovaItaly

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