Multiple sclerosis and autoimmune diseases
- 151 Downloads
An autoimmune background is thought to characterize the families of multiple sclerosis (MS) patients, but disease patterns and HLA–DR association seem to vary considerably among different ethnic groups. We investigated the prevalence of autoimmune diseases in 245 MS patients and 245 age– and sex–matched normal controls (NC), originating from and living in North–east Italy, and their first degree relatives, using a case–control method. Further, HLA–DRB1 expression was analysed in MS and NC. The following significant findings were observed: 1) a significant excess of autoimmunity in firstdegree relatives of MS patients (p = 0.000), 2) an association of MS with Type 1 diabetes mellitus (T1DM) (p = 0.02), 3) an increase in DR4 expression (namely DRB1*0401) in MS patients from families with multiple autoimmune pathology compared with reference MS patients (p=0.02) and NC (p=0.01).We conclude that the risk of autoimmune disease is higher in first–degree relatives of MS patients and that disease association and HLA–DR expression in North–east Italy differs from other geographic regions of Europe.
Key wordsmultiple sclerosis autoimmune disease epidemiology HLA–DR
Unable to display preview. Download preview PDF.
- 19.Bennucci M, Li Gobbi F, Del Rosso A, Manfredi M (2005) Systemic lupus erythematous: the first: the first Italian prevalence study. Reumatism 57:103–108Google Scholar
- 21.Cucca F, Todd JA (1996) HLA susceptibility to type 1 diabetes: methods and mechanisms. In: Browning MJ, McMichaels AJ, (eds) HLA/MHC: gene, molecules and function. Oxford BIOS Scientific Publishers, pp 383–406Google Scholar