Journal of Neurology

, Volume 253, Issue 5, pp 590–593 | Cite as

Intracranial lipomas and epilepsy

  • T. LoddenkemperEmail author
  • H. H. MorrisIII
  • B. Diehl
  • D. K. Lachhwani



Intracranial lipomas are rare, mostly congenital lesions. Sporadic case reports suggest an association with focal epilepsy.


All admissions to our epilepsy monitoring unit who had had brain MRI were reviewed for intracranial lipomas during 6 consecutive years.


Five patients with intracranial lipomas were identified (0. 14 %). Lipomas were located in the midline (3 cases), in the tectal region [1], and over the parietal cortex [1]. Another intracranial pathology was identified in two patients causing the epilepsy in these cases (head trauma and hemimegaencephaly). In two other cases the Video EEG monitoring findings were not congruent with the location of the lipoma, but no other explanation for their epilepsy was found. In one patient a large midline lipoma extending into the right lateral ventricle was thought to be the cause of the patient’s right hemispheric seizures. No other clinical symptoms or complications of the lipomas were noted.


Intracranial lipomas are rare, incidental, often asymptomatic findings and usually located near the midline. In only one of our five patients was the lipoma interpreted as the definite cause of the epilepsy.

Key words

lipoma epilepsy seizure MRI 


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  1. 1.
    Bakshi R, Shaikh ZA, Kamran S, Kinkel PR (1999) MRI findings in 32 consecutive lipomas using conventional and advanced sequences. J Neuroimaging 9:134–140PubMedGoogle Scholar
  2. 2.
    Britt PM, Bindal AK, Balko MG, Yeh HS (1993) Lipoma of the cerebral cortex: case report. Acta Neurochir (Wien) 121:88–92CrossRefGoogle Scholar
  3. 3.
    Budka H (1974) Intracranial lipomatous hamartomas (intracranial “lipomas”). A study of 13 cases including combinations with medulloblastoma, colloid and epidermoid cysts, angiomatosis and other malformations. Acta Neuropathol (Berl) 28:205–222PubMedCrossRefGoogle Scholar
  4. 4.
    Donati F, Vassella F, Kaiser G, Blumberg A (1992) Intracranial lipomas. Neuropediatrics 23:32–38PubMedCrossRefGoogle Scholar
  5. 5.
    Eghwrudjakpor PO, Kurisaka M, Fukuoka M, Mori K (1991) Intracranial lipomas. Acta Neurochir (Wien) 110:124–128CrossRefGoogle Scholar
  6. 6.
    Feldman RP, Marcovici A, LaSala PA (2001) Intracranial lipoma of the sylvian fissure. Case report and review of the literature. J Neurosurg 94:515–519PubMedGoogle Scholar
  7. 7.
    Fujii Y, Konishi Y, Kuriyama M, Hori C, Sudo M (1993) Lipoma on surface of centroparietal lobes. Pediatr Neurol 9:144–146PubMedCrossRefGoogle Scholar
  8. 8.
    Gastaut H, Regis H, Gastaut JL, Yermenos E, Low MD (1980) Lipomas of the corpus callosum and epilepsy. Neurology 30:132–138PubMedGoogle Scholar
  9. 9.
    Gerber SS, Plotkin R (1982) Lipoma of the corpus callosum. Case report. J Neurosurg 57:281–285PubMedGoogle Scholar
  10. 10.
    Gomez–Gosalvez FA, Menor–Serrano F, Tellez de Meneses–Lorenzo M, Aleu Perez–Gramunt M, Sala–Sanchez AG, Rubio–Soriano A, Carbonell–Nadal J, Mulas F (2003) Intracranial lipomas in paediatrics: a retrospective study of 20 patients. Rev Neurol (Paris) 37:515–521PubMedGoogle Scholar
  11. 11.
    Guye M, Gastaut JL, Bartolomei F (1999) Epilepsy and perisylvian lipoma/cortical dysplasia complex. Epileptic Disord 1:69–73PubMedGoogle Scholar
  12. 12.
    Halmagyi M, Evans W (1978) Lipoma of the quadrigeminal plate causing progressive obstructive hydrocephalus: case report. J Neurosurg 49:453–456PubMedCrossRefGoogle Scholar
  13. 13.
    Hood MN, Ho VB, Smirniotopoulos JG, Szumowski J (1999) Chemical shift: the artifact and clinical tool revisited. Radiographics 19:357–371PubMedGoogle Scholar
  14. 14.
    Kazner E, Stochdorph O, Wende S, Grumme T (1980) Intracranial lipoma. Diagnostic and therapeutic considerations. J Neurosurg 52:234–245PubMedCrossRefGoogle Scholar
  15. 15.
    Prabu SS, O’Donovan DG, Gurusinghe NT (1995) Intracranial angiolipoma: report of two cases. Br J Neurosurg 9:793–797PubMedCrossRefGoogle Scholar
  16. 16.
    Rokitansky C (1856) Lehrbuch der pathologischen Anatomie, p 468Google Scholar
  17. 17.
    Saatci I, Aslan C, Renda Y, Besim A (2000) Parietal lipoma associated with cortical dysplasia and abnormal vasculature: case report and review of the literature. AJNR Am J Neuroradiol 21:1718–1721PubMedGoogle Scholar
  18. 18.
    Sarioglu AC, Kaynar MY, Hanci M, Uzan M (1999) Sylvian fissure lipomas: case reports and review of the literature. Br J Neurosurg 13:386–388PubMedCrossRefGoogle Scholar
  19. 19.
    Sasaki H, Yoshida K, Wakamoto H, Otani M, Toya S (1996) Lipomas of the frontal lobe. Clin Neurol Neurosurg 98:27–31CrossRefGoogle Scholar
  20. 20.
    Tahmouresie A, Kroll G, Shucart W (1979) Lipoma of the corpus callosum. Surg Neurol 11:31–34PubMedGoogle Scholar
  21. 21.
    Truwit CL, Barkovich AJ (1990) Pathogenesis of intracranial lipoma: an MR study in 42 patients. AJR Am J Roentgenol 155:855–864PubMedGoogle Scholar
  22. 22.
    Vela–Yebra R, Pastor–Pons E, Altuzarra– Corral A, Garcia del Moral–Garrido R, Hervas–Navidad R, Sanchez–Alvarez JC (2002) Lipoma of the cerebral convexity and refractory focal epilepsy. Rev Neurol Paris 34:742–745Google Scholar
  23. 23.
    Warakaulle DR, Anslow P (2003) Differential diagnosis of intracranial lesions with high signal on T1 or low signal on T2–weighted MRI. Clin Radiol 58:922–933PubMedCrossRefGoogle Scholar
  24. 24.
    Wilberger JE Jr, Abla A, Kennerdell J, Maroon JC (1985) Mucocele of the pterygoid recess treated by laser surgery. Case report. J Neurosurg 63:970–972Google Scholar

Copyright information

© Steinkopff-Verlag 2006

Authors and Affiliations

  • T. Loddenkemper
    • 1
    Email author
  • H. H. MorrisIII
    • 1
  • B. Diehl
    • 1
  • D. K. Lachhwani
    • 1
  1. 1.Section of EpilepsyThe Cleveland Clinic FoundationClevelandUSA

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