Journal of Neurology

, Volume 253, Issue 4, pp 464–470 | Cite as

Neuropsychological function in relation to serum parathyroid hormone and serum 25–hydroxyvitamin D levels

The Tromsø study
  • R. JordeEmail author
  • K. Waterloo
  • F. Saleh
  • E. Haug
  • J. Svartberg


There are receptors for parathyroid hormone (PTH) and 1,25–dihydroxyvitamin D in the brain, and there are clinical and experimental data indicating that PTH and vitamin D may affect cerebral function. In the present study 21 subjects who both in the 5th Tromsø study and at a follow–up examination fulfilled criteria for secondary hyperparathyroidism (SHPT) without renal failure (serum calcium < 2.40 mmol/L, serum PTH > 6.4 pmol/L, and normal serum creatinine) and 63 control subjects were compared with tests for cognitive and emotional function. Those in the SHPT group had significantly impaired performance in 3 of 14 cognitive tests (Digit span forward, Stroop test part 1 and 2, and Word association test (FAS)) as compared with the controls, and also had a significantly higher depression score at the Beck Depression Inventory (BDI) (items 1–13). In a multiple linear regression model, a high serum PTH level was significantly associated with low performance at the Digit span forward, Stroop test part 1 and 2, and Digit Symbol tests. A low level of serum 25–hydroxyvitamin D was significantly associated with a high depression score. In conclusion, a deranged calcium metabolism appears to be associated with impaired function in several tests of neuropsychological function.

Key words

cognitive function depression emotional function parathyroid hormone vitamin D 


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Copyright information

© Steinkopff-Verlag 2006

Authors and Affiliations

  • R. Jorde
    • 1
    • 2
    Email author
  • K. Waterloo
    • 3
  • F. Saleh
    • 2
  • E. Haug
    • 4
  • J. Svartberg
    • 2
  1. 1.Department of Internal MedicineInstitute of Clinical Medicine, University of TromsøTromsøNorway
  2. 2.Department of Internal Medicine BUniversity Hospital of North NorwayTromsøNorway
  3. 3.Department of NeurologyInstitute of Clinical Medicine, University of TromsøTromsøNorway
  4. 4.Hormone LaboratoryAker University HospitalOsloNorway

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