Journal of Neurology

, Volume 251, Supplement 2, pp ii25–ii30 | Cite as

Impact of neutralizing antibodies on the clinical efficacy of interferon beta in multiple sclerosis

  • Timothy Vartanian
  • Per Sölberg Sørensen
  • George Rice


Neutralizing antibodies (NAbs) can develop in a large proportion of patients with MS who receive treatment with interferon beta (IFNβ). Data show that IFNβ-1b is more immunogenic than IFNβ-1a and that IFNβ-1a-Rebif® is more immunogenic than IFNβ-1a-Avonex®. This article reviews the long-term data from large phase III clinical trials showing that NAbs can reduce the clinical efficacy of IFNβ in patients with MS; patients who have a positive result on NAb testing have a higher relapse rate and more disease activity, as measured by brain MRI, than do patients with a negative result. The detrimental effects of NAbs were not observed until after 18 months of treatment, suggesting that short-term clinical trials cannot adequately assess the efficacy of IFNβ products in MS. Clinicians should consider the possible development of NAbs when starting patients on treatment and in patients with disease progression while on IFNβ treatment.

Key words

multiple sclerosis interferon beta neutralizing antibodies immunogenicity protein therapeutics 

Copyright information

© Steinkopff Verlag 2004

Authors and Affiliations

  • Timothy Vartanian
    • 1
    • 4
  • Per Sölberg Sørensen
    • 2
  • George Rice
    • 3
  1. 1.Beth Israel-Deaconess, Harvard Institute of MedicineBostonUSA
  2. 2.Department of NeurologyRigshospitaletCopenhagenDenmark
  3. 3.Multiple Sclerosis ClinicUniversity of Western OntarioLondonCanada
  4. 4.Beth Israel-DeaconessHarvard Institute of MedicineBostonUSA

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