Journal of Neurology

, Volume 249, Issue 11, pp 1535–1540

Circadian heart rate variability in Parkinson's disease

  • Ville Pursiainen
  • Tarja H. Haapaniemi
  • Juha T. Korpelainen
  • Heikki V. Huikuri
  • Kyösti A. Sotaniemi
  • Vilho V. Myllylä
ORIGINAL COMMUNICATION

Abstract.

Parkinson's disease is known to affect the reflex cardiovascular control systems, resulting in a suppressed heart rate variability, but present knowledge concerning the long-term characteristics of heart rate and heart rate variability, e. g. circadian regulation, is limited.

We investigated the circadian fluctuation of the time domain, frequency domain and some non-linear measures of heart rate variability in 44 untreated patients with Parkinson's disease and 43 age- and sex-matched control subjects.

In the parkinsonian patients, the measured power spectral components of heart rate variability (low-frequency power and high-frequency power) and the SD1 value of the Poincaré two dimensional vector analysis, that quantifies the short term beat-to-beat variability, were suppressed at night. During the daytime only the SD1 of the Poincaré was suppressed. The night-to-day-ratios of the heart rate variability measures did not differ significantly between the patients and the controls.

The results indicate that the long-term parasympathetic cardiovascular regulation is impaired in untreated patients with Parkinson's disease. The dysfunction is more pronounced at night.

Key words Parkinson's disease autonomic nervous system heart rate variability circadian fluctuation 

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Copyright information

© Steinkopff Verlag 2002

Authors and Affiliations

  • Ville Pursiainen
    • 1
  • Tarja H. Haapaniemi
    • 1
  • Juha T. Korpelainen
    • 1
  • Heikki V. Huikuri
    • 2
  • Kyösti A. Sotaniemi
    • 1
  • Vilho V. Myllylä
    • 1
  1. 1.Department of Neurology, University of Oulu, P. O. Box 5000, 90014 Oulu, FinlandFI
  2. 2.Department of Medicine, Division of Cardiology, University of OuluFI

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