Journal of Neurology

, Volume 249, Issue 11, pp 1493–1502

Skeletal muscle channelopathies

  • Karin Jurkat-Rott
  • Holger Lerche
  • Frank Lehmann-Horn
ENS TEACHING REVIEW

Abstract.

Ion channelopathies have common clinical features, recurrent patterns of mutations, and almost predictable mechanisms of pathogenesis. In skeletal muscle, disorders are associated with mutations in voltage-gated Na+, K+, Ca2+, and Cl channels leading to hypoexcitability, causing periodic paralysis and to hyperexcitabilty, resulting in myotonia or susceptibility to malignant hyperthermia.

Key words ionchannels hereditary diseases sodium potassium calcium chloride 

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Copyright information

© Steinkopff Verlag 2002

Authors and Affiliations

  • Karin Jurkat-Rott
    • 1
  • Holger Lerche
    • 1
  • Frank Lehmann-Horn
    • 1
  1. 1.Department of Applied Physiology, University of Ulm, 89069 Ulm, GermanyDE
  2. 2.Department of Neurology, University of Ulm, 89069 Ulm, GermanyDE

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