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Journal of Neurology

, Volume 249, Issue 8, pp 1063–1065 | Cite as

Reversible white matter alterations in encephalopathy associated with autoimmune thyroid disease

  • Patricia Pozo-Rosich
  • Pablo Villoslada
  • Ana Canton
  • Rafael Simo
  • Alex Rovira
  • Xavier Montalban
ORIGINAL COMMUNICATION

Abstract

Encephalopathy associated with autoimmune thyroid disease is an underdiagnosed clinical condition. No specific disease marker exists and to date, imaging techniques have not proven useful. The disease is characterized by seizures, stroke-like events and psychiatric symptoms. Here, we present the report of a patient with encephalopathy associated with autoimmune thyroid disease in which a reversible white matter disorder was detected by MR imaging. This encephalopathy was alleviated and later disappeared following corticosteroid treatment. We conclude that the white matter is the principal brain tissue involved in this condition and that brain MRI studies may prove to be a useful tool in the diagnosis of patients suffering this treatable disease.

Key words encephalopathy autoimmune thyroid disease Hashimoto encephalopathy MRI anti-tiroglobulin antibodies anti-microsomal antibodies 

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Copyright information

© Steinkopff Verlag 2002

Authors and Affiliations

  • Patricia Pozo-Rosich
    • 1
  • Pablo Villoslada
    • 1
  • Ana Canton
    • 2
  • Rafael Simo
    • 2
  • Alex Rovira
    • 3
  • Xavier Montalban
    • 1
  1. 1.Clinical Neuroimmunology Unit Hospital Vall d'Hebron Ps Vall d'Hebron 119 08035 Barcelona, Spain Tel.: +34-93/2746202 Fax: +34-93/2746084 E-Mail: xmontal@hg.vhebron.es E-Mail: esclerosimultiple@hg.vhebron.esES
  2. 2.Department of Endocrinology Hospital Vall d'Hebron Ps Vall d'Hebron 119 08035 Barcelona, SpainES
  3. 3.Magnetic Resonance Center (IDI) Hospital Vall d'Hebron Ps Vall d'Hebron 119 08035 Barcelona, SpainES

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