Journal of Neurology

, Volume 249, Issue 7, pp 801–804

Association study between iron-related genes polymorphisms and Parkinson's disease

  • Claire Borie
  • Francesca Gasparini
  • Patrice Verpillat
  • Anne-Marie Bonnet
  • Yves Agid
  • Gilles Hetet
  • Alexis Brice
  • Alexandra Dürr
  • Bernard Grandchamp
  • and the French Parkinson's disease genetic study group
ORIGINAL COMMUNICATION

DOI: 10.1007/s00415-002-0704-6

Cite this article as:
Borie, C., Gasparini, F., Verpillat, P. et al. J Neurol (2002) 249: 801. doi:10.1007/s00415-002-0704-6

Abstract.

We have conducted a case-control study in order to test for an association between 8 intragenic polymorphisms of 5 iron-related genes (transferrin, transferrin receptor1, HFE, frataxin and lactoferrin) and Parkinson disease. Comparison of genotypes and allele frequencies did not differ significantly between cases and controls for all studied polymorphisms except the G258S transferrin polymorphism, for which a higher frequency of the G allele was found among cases (p=0.033), particularly among cases with onset older than 60 (p=0.0017) and with negative family history (p=0.022). This finding suggests that genetic variations in the control of iron metabolism may contribute to the pathogenesis of the disease.

Key words Parkinson Iron Polymorphism Transferrin Genetics 

Copyright information

© Steinkopff Verlag 2002

Authors and Affiliations

  • Claire Borie
    • 1
  • Francesca Gasparini
    • 2
  • Patrice Verpillat
    • 3
  • Anne-Marie Bonnet
    • 2
  • Yves Agid
    • 2
  • Gilles Hetet
    • 1
  • Alexis Brice
    • 2
  • Alexandra Dürr
    • 2
  • Bernard Grandchamp
    • 1
  • and the French Parkinson's disease genetic study group
  1. 1.INSERM U409, association Claude Bernard, Faculté de Médecine Bichat, B. P. 416, 75 870 Paris cedex 18. Tel.: +33-1/44 85 63 42, Fax: +33-1/42 26 46 24, E-Mail bgrandch@bichat.inserm.frFR
  2. 2.INSERM U289, Hôpital de la Salpêtrière, ParisFR
  3. 3.Department of Biostatistics, and Epidemiology, IFR 02 – CHU Xavier Bichat, ParisFR
  4. 4.Fédération de Neurologie, Hôpital de la Salpêtrière, ParisFR
  5. 5.Département de Génétique, Cytogénétique et Embryologie, Hôpital de la Salpêtrière, ParisFR

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