International Journal of Legal Medicine

, Volume 111, Issue 3, pp 124–132 | Cite as

Population data for 101 Austrian Caucasian mitochondrial DNA d-loop sequences: Application of mtDNA sequence analysis to a forensic case

  • W. Parson
  • T. J. Parsons
  • R. Scheithauer
  • M. M. Holland
Original article

Abstract

The sequence of the two hypervariable segments of the mitochondrial DNA (mtDNA) control region was generated for 101 random Austrian Caucasians. A total of 86 different mtDNA sequences was observed, where 11 sequences were shared by more than 1 individual, 7 sequences were shared by 2 individuals and 4 sequences were shared by 3 individuals. One of the four most common mtDNA sequences in Austrians is also the most common sequence in both U.S. and British Caucasians, found in approximately 3.0% of Austrians, 4.0% of British, and 3.9% of U.S. Caucasians. Of the remaining three common Austrian sequences, one was not observed in either U.S. or British Caucasians. However, three British Caucasians exhibited a similar sequence type. Therefore, this particular cluster of sequence polymorphisms may represent a common “European” mtDNA sequence type. In general, Austrian Caucasians show little deviation from other Caucasian databases of European descent. Finally, mtDNA sequence analysis was applied to a forensic case, where hairs found at a crime scene matched the control hairs from the suspect.

Key words Mitochondrial DNA Heteroplasmy mtDNA Population frequency estimates Forensic casework 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • W. Parson
    • 1
  • T. J. Parsons
    • 2
  • R. Scheithauer
    • 1
  • M. M. Holland
    • 2
  1. 1.Institute for Forensic Medicine, University of Innsbruck, Muellerstrass 44, A-6020 Innsbruck, AustriaAT
  2. 2.The Armed Forces DNA Identification Laboratory, Armed Forces Institute of Pathology, 1413 Research Blvd., Rockville, Maryland, USA 20 850D3125US

Personalised recommendations