International Journal of Legal Medicine

, Volume 110, Issue 6, pp 299–304

Time dependence of the expression of ICAM-1 (CD 54) in human skin wounds

  • J. Dreßler
  • L. Bachmann
  • M. Kasper
  • J. G. Hauck
  • E. Müller
Original article

DOI: 10.1007/s004140050092

Cite this article as:
Dreßler, J., Bachmann, L., Kasper, M. et al. Int J Leg Med (1997) 110: 299. doi:10.1007/s004140050092

Abstract

To characterize the vitality and age of skin wounds by means of the ICAM-1 pattern, 157 intravital human skin wounds (time since injury ranging from 5 min to 730 days) were immunohistochemically investigated. ICAM-1 was detected in paraffin sections after autoclaving and using the ABC technique in 86% of the wounds investigated. The correlation between ICAM-1 expression and the degree of wound inflammation is weak. Strong positive staining was observed 1.5 h at the earliest and 3.5 days at the latest after the time of injury. ICAM-1 also appeared at low concentrations in samples of uninjured skin (n = 65), on keratinocytes and the endothelial cells of blood vessels. Moderate to strong ICAM-1 expression is a valuable indication of the vitality of the wound. However, at present the detection of ICAM-1 alone is not sufficient to fix the wound age with the accuracy which is required for forensics applications.

Key words ICAM-1 CD 54 Wound age Immunohistochemistry 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • J. Dreßler
    • 1
  • L. Bachmann
    • 2
  • M. Kasper
    • 3
  • J. G. Hauck
    • 1
  • E. Müller
    • 1
  1. 1.Department of Legal Medicine, Technical University Medical School, Fetscherstrasse 74, D-01307 Dresden, Germany FAX: +49 (351) 458 4325DE
  2. 2.Department of Surgery, Technical University Medical School, Fetscherstrasse 74, D-01307 Dresden, GermanyDE
  3. 3.Department of Pathology, Technical University Medical School, Fetscherstrasse 74, D-01307 Dresden, GermanyDE

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