Genetic diversity and haplotype analysis of Guizhou Miao identified with 19 X-chromosomal short tandem repeats
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We analyzed Chinese Miao population samples (n = 268) from Guizhou province, Southwest China, with 19 X-chromosomal short tandem repeats (STRs) included in the AGCU X19 amplification kit. The combined PE is 0.999999922 and the combined PDs in males and females are 0.9999999999999999999994 and 0.9999999999998, respectively. The mean paternity exclusion change values are larger than 0.99999996. The HDs in seven linkage groups vary from 0.9324 to 0.9968. Subsequently, comparison among different Chinese populations shows that the substructures of Chinese were significantly influenced by ethno-linguistic rather than geographical boundaries, including most prominently Turkic-speaking and Tibeto-Burman-speaking populations.
KeywordsX-chromosomal STRs Miao population Population genetics Haplotype diversity
This study received the support of grants from the National Natural Science Foundation of China (No. 81401562), the Fundamental Research Funds for the Central University (2012017yjsy187), the Science and Technology Foundation of Guizhou Province (No. 2013-2313), and the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry (No. 2014-1685).
Compliance with ethical standards
This study had been approved by the institutional review boards at Zunyi Medical University. Informed consent was obtained from volunteers before sample collection.
The authors declare that they have no competing interests.
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