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International Journal of Legal Medicine

, Volume 132, Issue 5, pp 1391–1403 | Cite as

Towards multi-phase postmortem CT angiography in children: a study on a porcine model

  • F. Z. Mokrane
  • L. Dercle
  • O. Meyrignac
  • É. Crubézy
  • H. Rousseau
  • N. Telmon
  • F. Dedouit
Original Article

Abstract

Purpose

Multi-phase postmortem computed tomography angiography (MPMCTA) is a growing technique, which is standardized for adults. Application of this protocol for a children population is not so well defined. Our study aims to adapt the adult’s protocol to children, using a porcine model.

Material and methods

Three groups of 18 pigs were studied, with a weight distribution between 4 and 48 kg. Different pump devices were used. Pigs of group I were studied using the Virtangio® machine, whereas pigs of groups II and III were studied using used the Medrad® machine. Study of vascular opacification was possible using a semi-quantitative method based on 26 arterial and 26 venous segments that were distributed over the entire body from the cephalic extremity to the posterior pawns.

Results

While thoracic, abdominal, and pelvic vascular opacification were complete for each individual pig in a group, group III showed better vascular opacification for the cephalic extremity. This was also true for anterior and posterior pawns vascular opacification. Spearman correlation tests showed a significant relationship between anthropometric characteristics of pigs, injection parameters, and percentage of opacified segments. A higher percentage of opacification was obtained for individuals of lower weights, with comparatively lower quantities of contrast agent injected.

Conclusion

Postmortem computed tomography angiography (PMCTA) was possible for all the individuals, particularly for small weights (4 kg) using the Medrad® machine. However, further studies are needed to better understand the procedure.

Keywords

Postmortem CT Angiography Porcine model Adults Children 

Supplementary material

414_2018_1783_Fig8_ESM.gif (52 kb)
Fig. 8

(supplementary material): Pig III-5 (4.7 kg). Anterior limbs vascular opacification. Axial (Fig. 8a on the left) and coronal (Fig. 8b on the right) reconstructions using thick MIP mode at the arterial time MPMCTA. Subclavian arteries are well opacified (white dotted arrows), as well as their division branches intended for the roots of limbs (white dotted circles). The distal third of the limbs is clearly opacified (white arrows). Figure 8c. Sagittal reconstruction using thick MIP mode at the venous time of MPMCTA focused on anterior right limb (ipsilateral). Visualization of arterial opacification of the distal third of the limb (yellow arrow), whereas the superficial venous network is only seen at the middle third/distal third junction of the limb (yellow dotted arrow). (GIF 52 kb)

414_2018_1783_MOESM1_ESM.tif (6.1 mb)
High Resolution Image (TIFF 6222 kb)
414_2018_1783_Fig9_ESM.gif (143 kb)
Fig. 9

(supplementary material): Posterior limbs vascular opacification. Figure 9a and b: Pig III-3 (7.1 kg). Sagittal oblique (Fig. 9a) and coronal (Fig. 9b) reconstructions of the right posterior limb in thick MIP mode at the arterial time of MPMCTA. Distal third arteries are opacified (white arrows). Figure 9c: Pig III-4 (5.2 kg). Sagittal reconstructions in thick MIP mode at the venous time of MPMCTA focused on the posterior left limb (contralateral). The primary iliac vein (white arrowhead) and the external iliac vein (white dotted arrow) are opacified. The veins of the proximal third of limb are also well visualized (white dotted circle). (GIF 142 kb)

414_2018_1783_MOESM2_ESM.tif (2.6 mb)
High Resolution Image (TIFF 2708 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • F. Z. Mokrane
    • 1
    • 2
  • L. Dercle
    • 3
    • 4
  • O. Meyrignac
    • 1
  • É. Crubézy
    • 2
  • H. Rousseau
    • 1
  • N. Telmon
    • 2
    • 5
  • F. Dedouit
    • 2
    • 6
  1. 1.Radiology DepartmentRangueil University HospitalToulouseFrance
  2. 2.French National Center for Scientific ResearchAMIS Laboratory: University of ToulouseToulouseFrance
  3. 3.Gustave Roussy InstituteUniversité Paris-SaclayVillejuifFrance
  4. 4.New York Presbyterian HospitalColumbia UniversityNew YorkUSA
  5. 5.Forensic DepartmentRangueil University HospitalToulouseFrance
  6. 6.Unit of Forensic and Anthropological ImagingCentre universitaire romand de médecine légale (CURML)Lausanne 25Switzerland

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