How many single nucleotide polymorphisms (SNPs) are needed to replace short tandem repeats (STRs) in forensic applications?
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Short tandem repeats (STRs) are the most commonly used forms of genetic information in forensic identification. In recent times, advances in the information on single nucleotide polymorphisms (SNPs) have raised the possibility that these markers could replace the forensically established STRs. In this work, we conducted comparative simulation studies that allowed us to estimate the number of SNPs needed if these markers were used instead of STRs in criminal cases and paternity investigations.
KeywordsShort tandem repeats Single nucleotide polymorphisms
This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science, ICT & Future Planning (2012-0009833), the research project for practical use and advancement of forensic DNA analysis of Supreme Prosecutors’ Office, Republic of Korea (1333-304-260, 2014), and the National Research Foundation (NRF) grant funded by the Korea government (MSIP, 2016943438).
- 5.Lisa DW, John MS, Jeffrey JT, Rick WS (1998) Human identification by genotyping single nucleotide polymorphisms (SNPs) using an APEX microarray. Genetic Identity Conference Proceedings, Ninth International Symposium on Human IdentificationGoogle Scholar
- 7.Brenner CH (1999) The power of SNP’s—even without population data. Poster presentation at the 10th Promega Symposium on Human identificationGoogle Scholar
- 8.Evett IW, Weir BS (1998) Interpreting DNA evidence. Sinauer Associates, Sunderland, MSGoogle Scholar
- 9.Lee JW, Lee HS (1999) The DNA profiling for paternity testing. Korean Lawyers Association J 512:134–154Google Scholar
- 16.Kruger J, Fuhrman W, Lichte KH, Steffens C (1968) Zur Verwendung des Polymorphisms der sauren Erythrocytenphosphatase bei der Vaterschaftsbegutachtung. Dtsch Z Gerichtl Med 64:127–146Google Scholar