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International Journal of Legal Medicine

, Volume 130, Issue 1, pp 23–26 | Cite as

Tri-allelic patterns at the D7S820 locus detected in two generations of a Chinese family

  • Erlie Jiang
  • Jie Pan
  • Mingzhe Han
  • Liang Chen
  • Qiaoling Ma
  • Jialin Wei
  • Yong Huang
  • Sizhou Feng
  • Qin Sun
  • Peili Xiao
  • Zhongzheng ZhengEmail author
Original Article

Abstract

Alleles at the D7S820 STR locus have 6–14 different numbers of a four-nucleotide (GATA) repeat motif arranged in tandem. The D7S820 tri-allelic pattern is rare and has not been reported in the Chinese population. In this study we report a three-banded pattern at the D7S820 locus observed in a Chinese family, in which four family members in two generations had tri-allelic D7S820 genotype 10-11-12 and one family member had an abnormal bi-allele genotype 10–11. All of the four tri-allelic cases had the genotype 10-11-12, probably due to three copies of the D7S820 STR sequence in all cells (Type 2 tri-allelic pattern), and deduced alleles 10–11 were a linked inheritance in this family.

Keywords

Tri-allelic patterns DNA typing Short tandem repeat (STR) D7S820 locus 

Notes

Acknowledgments

This article presents independent research funded by the Shanghai Tissuebank Biotechnology Co.,LTD and supported by the Tianjin Hematonosis Hospital Hematology Department. The views expressed are those of the author(s).

Ethical standards

This study complies with the current laws and ethical standards required in China.

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Erlie Jiang
    • 1
  • Jie Pan
    • 2
  • Mingzhe Han
    • 1
  • Liang Chen
    • 1
  • Qiaoling Ma
    • 1
  • Jialin Wei
    • 1
  • Yong Huang
    • 1
  • Sizhou Feng
    • 1
  • Qin Sun
    • 2
  • Peili Xiao
    • 2
  • Zhongzheng Zheng
    • 2
    Email author
  1. 1.Department of HematologyTianjin Hematonosis HospitalTianjinChina
  2. 2.DNA Typing LaboratoryShanghai Tissuebank Biotechnology Co., LTDShanghaiChina

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