International Journal of Legal Medicine

, Volume 128, Issue 4, pp 599–606

Negative autopsy and sudden cardiac death

  • Oscar Campuzano
  • Catarina Allegue
  • Sara Partemi
  • Anna Iglesias
  • Antonio Oliva
  • Ramon Brugada
Review Article


Forensic medicine defines the unexplained sudden death as a death with a non-conclusive diagnosis after autopsy. Molecular diagnosis is being progressively incorporated in forensics, mainly due to improvement in genetics. New genetic technologies may help to identify the genetic cause of death, despite clinical interpretation of genetic data remains the current challenge. The identification of an inheritable defect responsible for arrhythmogenic syndromes could help to adopt preventive measures in family members, many of them asymptomatic but at risk of sudden death. This multidisciplinary translational research requires a specialized team.


Negative autopsy Sudden cardiac death Channelopathies Genetics 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Oscar Campuzano
    • 1
  • Catarina Allegue
    • 1
  • Sara Partemi
    • 2
  • Anna Iglesias
    • 1
  • Antonio Oliva
    • 2
  • Ramon Brugada
    • 1
    • 3
    • 4
  1. 1.Cardiovascular Genetic CenterUniversity of Girona-IDIBGIGironaSpain
  2. 2.Institute of Public Health, Section of Legal MedicineCatholic UniversityRomeItaly
  3. 3.Medical SchoolUniversitat de GironaGironaSpain
  4. 4.Cardiovascular Genetics CenterInstitut d’Investigació Biomèdica Girona-IdIBGiGironaSpain

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