International Journal of Legal Medicine

, Volume 125, Issue 1, pp 143–147 | Cite as

Software for Y-haplogroup predictions: a word of caution

  • Marina Muzzio
  • Virginia Ramallo
  • Josefina M. B. Motti
  • Maria R. Santos
  • Jorge S. López Camelo
  • Graciela Bailliet
SHORT COMMUNICATION

Abstract

The development of online software designed for genetic studies has been exponentially growing, providing numerous benefits to the scientific community. However, they should be used with care, since some require adjustments. The efficiency of two programs for haplogroup prediction was tested with 119 samples of known haplotypes and haplogroups from Argentine populations. Quantitative estimates of the predictive quality of both software systems were computed with the uncertainty coefficient; and sensitivity, specificity, positive, and negative likelihood ratios were also calculated to assert the reliability of both programs, showing high probabilities of assigning an incorrect haplogroup.

Keywords

Molecular anthropology Population genetics Human Y-chromosome SNP/STR Bioinformatic approaches 

Supplementary material

414_2009_404_MOESM1_ESM.doc (260 kb)
ESM Table 3Profiles with haplotypes and haplogroups used for validation (DOC 259 kb)

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Marina Muzzio
    • 1
    • 2
  • Virginia Ramallo
    • 1
  • Josefina M. B. Motti
    • 1
  • Maria R. Santos
    • 1
  • Jorge S. López Camelo
    • 1
  • Graciela Bailliet
    • 1
  1. 1.Laboratorio de Genética Molecular PoblacionalInstituto Multidisciplinario de Biología Celular (IMBICE), CICPBA, CCTLa Plata–CONICETArgentina
  2. 2.Instituto Multidisciplinario de Biología Celular (IMBICE)La PlataArgentina

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