International Journal of Legal Medicine

, Volume 125, Issue 1, pp 121–125 | Cite as

A hypervariable STR polymorphism in the complement factor I (CFI) gene: Asian-specific alleles

  • Isao Yuasa
  • Yoshito Irizawa
  • Hiroaki Nishimukai
  • Yasuo Fukumori
  • Kazuo Umetsu
  • Nori Nakayashiki
  • Naruya Saitou
  • Lotte Henke
  • Jürgen Henke
Short Communication


In this study, a short tandem repeat (STR) polymorphism in intron 7 of the human complement factor I (CFI) gene was studied in 637 DNA samples obtained from African, German, Thai, and Japanese populations and German and Japanese families. A total of 41 alleles were observed and classified into two groups, L and H, based on size differences. Group H, which consisted of 16 alleles, was observed only in Thai and Japanese populations at frequencies of 0.162 and 0.116, respectively, and was strongly associated with c.1217A in exon 11 (CFI*Ah). The heterozygosity values ranged from 0.89 in German to 0.93 in Thai populations. This STR would be a useful supplementary marker for forensic individualization.


Asian-specific Complement factor I Microsatellite Population study Short tandem repeat 



This study was supported in part by a Grant-in-Aid for Scientific Research (20590678 to IY) from the Japan Society for the Promotion of Science.

Supplementary material

414_2009_369_MOESM1_ESM.doc (44 kb)
Table S1 Allele nomenclature, fragment length, and repeat composition of 113 PCR fragments (alleles 16-55.3) (DOC 44 kb)
414_2009_369_MOESM2_ESM.doc (32 kb)
Table S2 Comparison of nucleotide sequence in STR and its flanking regions (DOC 31 kb)
414_2009_369_MOESM3_ESM.doc (32 kb)
Table S3 Distribution of allele frequencies for SNPs and STR in the CFI gene and parameters of forensic interest (DOC 31 kb)


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Isao Yuasa
    • 1
  • Yoshito Irizawa
    • 1
  • Hiroaki Nishimukai
    • 2
  • Yasuo Fukumori
    • 3
  • Kazuo Umetsu
    • 4
  • Nori Nakayashiki
    • 5
  • Naruya Saitou
    • 6
  • Lotte Henke
    • 7
  • Jürgen Henke
    • 7
  1. 1.Division of Legal Medicine, Faculty of MedicineTottori UniversityYonagoJapan
  2. 2.Division of Legal MedicineEhime University School of MedicineEhimeJapan
  3. 3.Osaka Red Cross Blood CenterOsakaJapan
  4. 4.Department of Experimental and Forensic Pathology, Faculty of MedicineYamagata UniversityYamagataJapan
  5. 5.Department of Legal MedicineIwate Medical University School of MedicineMoriokaJapan
  6. 6.Division of Population GeneticsNational Institute of GeneticsMishimaJapan
  7. 7.Institut für BlutgruppenforschungCologneGermany

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