Interpretation of drug concentrations in an alternative matrix: the case of meprobamate in bile

  • L. Fanton
  • F. Bevalot
  • M. P. Gustin
  • C. Z. Paultre
  • C. Le Meur
  • D.  Malicier
Original Article

DOI: 10.1007/s00414-008-0259-x

Cite this article as:
Fanton, L., Bevalot, F., Gustin, M.P. et al. Int J Legal Med (2009) 123: 97. doi:10.1007/s00414-008-0259-x

Abstract

Investigating toxicological causes of death may require alternative matrices when the usual ones are lacking. Whereas forensic toxicology uses bile almost only for xenobiotic screening, a diagnostic test interpreting postmortem bile concentrations of meprobamate is reported. Based on 128 sets of autopsy data, its intrinsic qualities were good, with 0.95 sensitivity and 0.93 specificity. In a French forensic population, the positive and negative predictive factors were 0.90 and 0.97, respectively. It is a useful means of revealing overdoses where blood samples are not available or of confirming blood tests when postmortem redistribution is suspected.

Keywords

Meprobamate Bile Forensic toxicology Lethal intoxication Autopsy 

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • L. Fanton
    • 1
    • 2
  • F. Bevalot
    • 1
    • 2
    • 3
  • M. P. Gustin
    • 1
    • 4
  • C. Z. Paultre
    • 1
    • 4
  • C. Le Meur
    • 1
    • 2
    • 3
  • D.  Malicier
    • 1
    • 2
  1. 1.Université de LyonLyonFrance
  2. 2.Institut de Médecine LégaleUniversité Lyon 1LyonFrance
  3. 3.Institut de Médecine Légale, Unité de toxicologieUniversité Lyon 1LyonFrance
  4. 4.Institut des Sciences Pharmaceutiques et biologiques–ISPBUniversité Lyon 1LyonFrance

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