International Journal of Legal Medicine

, Volume 119, Issue 1, pp 50–53

Mitochondrial DNA CA dinucleotide repeats in Koreans: the presence of length heteroplasmy

  • Ukhee Chung
  • Hwan Young Lee
  • Ji-Eun Yoo
  • Myung Jin Park
  • Kyoung-Jin Shin
Short Communication

Abstract

The mitochondrial DNA HV3 region contains CA dinucleotide repeats which display length polymorphism. To analyze this for forensic purposes, we designed a fluorescence-labelled PCR primer set for short amplification products and carried out genotyping by using capillary electrophoresis. A total of 4 alleles with 4–7 repeat units were observed and the genetic diversity was estimated to be 0.5120 in 500 unrelated Koreans. Interestingly, three individuals showed two or three length variants, i.e. length heteroplasmy.

Keywords

Mitochondrial DNA CA dinucleotide repeats Length polymorphism Length heteroplasmy Koreans 

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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Ukhee Chung
    • 1
    • 2
  • Hwan Young Lee
    • 1
  • Ji-Eun Yoo
    • 1
  • Myung Jin Park
    • 1
  • Kyoung-Jin Shin
    • 1
    • 2
    • 3
  1. 1.Department of Forensic Medicine and Brain Korea 21 Project for Medical ScienceCollege of Medicine Yonsei UniversitySeoul Korea
  2. 2.Biometrics Engineering Research CenterYonsei UniversitySeoulKorea
  3. 3.Human Identification Research InstituteYonsei UniversitySeoul Korea

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