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Chromosoma

, Volume 128, Issue 3, pp 181–198 | Cite as

Crossing and zipping: molecular duties of the ZMM proteins in meiosis

  • Alexandra Pyatnitskaya
  • Valérie BordeEmail author
  • Arnaud De MuytEmail author
Review

Abstract

Accurate segregation of homologous chromosomes during meiosis depends on the ability of meiotic cells to promote reciprocal exchanges between parental DNA strands, known as crossovers (COs). For most organisms, including budding yeast and other fungi, mammals, nematodes, and plants, the major CO pathway depends on ZMM proteins, a set of molecular actors specifically devoted to recognize and stabilize CO-specific DNA intermediates that are formed during homologous recombination. The progressive implementation of ZMM-dependent COs takes place within the context of the synaptonemal complex (SC), a proteinaceous structure that polymerizes between homologs and participates in close homolog juxtaposition during prophase I of meiosis. While SC polymerization starts from ZMM-bound sites and ZMM proteins are required for SC polymerization in budding yeast and the fungus Sordaria, other organisms differ in their requirement for ZMM in SC elongation. This review provides an overview of ZMM functions and discusses their collaborative tasks for CO formation and SC assembly, based on recent findings and on a comparison of different model organisms.

Keywords

Meiosis Crossover Recombination Synaptonemal complex ZMM 

Notes

Acknowledgments

We thank Nancy Hollingsworth, Denise Zickler, and Wayne Crismani for critical reading of the manuscript.

Funding information

Work in the V.B. lab is funded by Institut Curie, CNRS, Labex DEEP (ANR-11-LBX-0044), ANR (ANR-15-CE11-0011), Projet Fondation ARC, La Ligue contre le Cancer, and Electricité de France. A. P. is funded by a doctoral fellowship from PSL University.

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© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Institut CuriePSL Research University, CNRS, UMR3244ParisFrance
  2. 2.Paris Sorbonne UniversitéParisFrance

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