, Volume 123, Issue 1–2, pp 79–90 | Cite as

Poly(ADP-ribosyl)ation in regulation of chromatin structure and the DNA damage response

  • Michael Tallis
  • Rosa Morra
  • Eva Barkauskaite
  • Ivan Ahel


Poly(ADP-ribose) (PAR) is a post-translational modification of proteins and is synthesised by PAR polymerases (PARPs), which have long been associated with the coordination of the cellular response to DNA damage, amongst other processes. Binding of some PARPs such as PARP1 to broken DNA induces a substantial wave of PARylation, which results in significant re-structuring of the chromatin microenvironment through modification of chromatin-associated proteins and recruitment of chromatin-modifying proteins. Similarly, other DNA damage response proteins are recruited to the damaged sites via PAR-specific binding modules, and in this way, PAR mediates not only local chromatin architecture but also DNA repair. Here, we discuss the expanding role of PAR in the DNA damage response, with particular focus on chromatin regulation.


Stall Replication Fork Catalytic PARP Domain Puff Locus NuRD Chromatin Remodelling Complex Chromatin Microenvironment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We are grateful to G. Timinszky and A. Jefferson for their helpful comments. This work was funded by Cancer Research UK and European Research Council (grant no. 281739).

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Michael Tallis
    • 1
  • Rosa Morra
    • 1
  • Eva Barkauskaite
    • 1
  • Ivan Ahel
    • 1
    • 2
  1. 1.Cancer Research UK, Paterson Institute for Cancer ResearchUniversity of ManchesterManchesterUK
  2. 2.Sir William Dunn School of PathologyUniversity of OxfordOxfordUK

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