Chromosoma

, Volume 122, Issue 5, pp 387–399 | Cite as

Multiple crosstalks between mRNA biogenesis and SUMO

  • Jérôme O. Rouvière
  • Marie-Claude Geoffroy
  • Benoit Palancade
Review
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Abstract

mRNA metabolism involves the orchestration of multiple nuclear events, including transcription, processing (e.g., capping, splicing, polyadenylation), and quality control. This leads to the accurate formation of messenger ribonucleoparticles (mRNPs) that are finally exported to the cytoplasm for translation. The production of defined sets of mRNAs in given environmental or physiological situations relies on multiple regulatory mechanisms that target the mRNA biogenesis machineries. Among other regulations, post-translational modification by the small ubiquitin-like modifier SUMO, whose prominence in several cellular processes has been largely demonstrated, also plays a key role in mRNA biogenesis. Analysis of the multiple available SUMO proteomes and functional validations of an increasing number of sumoylated targets have revealed the key contribution of SUMO-dependent regulation in nuclear mRNA metabolism. While sumoylation of transcriptional activators and repressors is so far best documented, SUMO contribution to other stages of mRNA biogenesis is also emerging. Modification of mRNA metabolism factors by SUMO determine their subnuclear targeting and biological activity, notably by regulating their molecular interactions with nucleic acids or protein partners. In particular, sumoylation of DNA-bound transcriptional regulators interfere with their association to target sequences or chromatin modifiers. In addition, the recent identification of enzymes of the SUMO pathway within specialized mRNA biogenesis machineries may provide a further level of regulation to their specificity. These multiple crosstalks between mRNA metabolism and SUMO appear therefore as important players in cellular regulatory networks.

Keywords

Sumoylation mRNA transcription mRNA processing Messenger ribonucleoparticle (mRNP) 

Abbreviations

hnRNP

Heterogenous nuclear ribonucleoprotein

mRNA

Messenger RNA

mRNP

Messenger ribonucleoparticle

NPC

Nuclear pore complex

RNAP II

RNA polymerase II

SIM

SUMO-interacting motif

STUbL

SUMO-targeted ubiquitin ligase

SUMO

Small ubiquitin-like modifier

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Notes

Acknowledgments

We thank Amandine Bonnet, Valérie Doye, Anne-Lise Haenni, and Françoise Stutz for critical reading of the manuscript and apologize to colleagues whose work was not directly cited due to space limitation. Our research is supported by the CNRS, the Fondation ARC pour la Recherche sur le Cancer (Grant “Projet ARC”, to B.P.) and La Ligue Contre le Cancer (comité du Val d'Oise, to B.P.). J.O.R is the recipient of a PhD fellowship from the Ministère de l'Enseignement Supérieur et de la Recherche.

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© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Jérôme O. Rouvière
    • 1
    • 2
  • Marie-Claude Geoffroy
    • 1
  • Benoit Palancade
    • 1
  1. 1.Institut Jacques Monod, CNRS, UMR 7592Univ Paris DiderotParisFrance
  2. 2.Ecole Doctorale Gènes Génomes CellulesUniversité Paris Sud-11OrsayFrance

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