Chromosoma

, 120:447 | Cite as

The template choice decision in meiosis: is the sister important?

Mini-Review

Abstract

Recombination between homologous chromosomes is crucial to ensure their proper segregation during meiosis. This is achieved by regulating the choice of recombination template. In mitotic cells, double-strand break repair with the sister chromatid appears to be preferred, whereas interhomolog recombination is favoured during meiosis. However, in the last year, several studies in yeast have shown the importance of the meiotic recombination between sister chromatids. Although this thinking seems to be new, evidences for sister chromatid exchange during meiosis were obtained more than 50 years ago in non-model organisms. In this mini-review, we comment briefly on the most recent advances in this hot topic and also describe observations which suggest the existence of inter-sister repair during meiotic recombination. For instance, the behaviour of mammalian XY bivalents and that of trivalents in heterozygotes for chromosomal rearrangements are cited as examples. The “rediscovering” of the requirement for the sister template, although it seems to occur at a low frequency, will probably prompt further investigations in organisms other than yeast to understand the complexity of the partner choice during meiosis.

List of abbreviations

AE

Axial element

BrdU

Bromodeoxyuridine

BSCR

Barrier to sister chromatid repair

CO

Crossover

dHJ

Double Holliday junction

DSB

Double-strand break

DSBR

DSB repair

FPG

Fluorescent plus Giemsa

IHR

Interhomolog recombination

NCO

Non-crossover

SC

Synaptonemal complex

SCE

Sister chromatid exchange

SDSA

Synthesis-dependent strand annealing

SEI

Single-end invasion

ssDNA

Single-strand DNA

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  1. 1.Departamento de Genética, Facultad de BiologíaUniversidad Complutense de MadridMadridSpain

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