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Chromosoma

, Volume 118, Issue 6, pp 683–692 | Cite as

H2AX: functional roles and potential applications

  • Jennifer S. DickeyEmail author
  • Christophe E. Redon
  • Asako J. Nakamura
  • Brandon J. Baird
  • Olga A. Sedelnikova
  • William M. BonnerEmail author
Mini-Review

Abstract

Upon DNA double-strand break (DSB) induction in mammals, the histone H2A variant, H2AX, becomes rapidly phosphorylated at serine 139. This modified form, termed γ-H2AX, is easily identified with antibodies and serves as a sensitive indicator of DNA DSB formation. This review focuses on the potential clinical applications of γ-H2AX detection in cancer and in response to other cellular stresses. In addition, the role of H2AX in homeostasis and disease will be discussed. Recent work indicates that γ-H2AX detection may become a powerful tool for monitoring genotoxic events associated with cancer development and tumor progression.

Keywords

Ionize Radiation Fanconi Anemia Ataxia Telangiectasia Mutate H2AX Phosphorylation Radiation Induce Bystander Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

This work was supported by the Intramural Research Program of the National Cancer Institute, NIH. We would like to thank Dr. Kurt Kohn for assistance with the design of the Molecular Interaction Map.

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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Jennifer S. Dickey
    • 1
    • 2
    Email author
  • Christophe E. Redon
    • 1
  • Asako J. Nakamura
    • 1
  • Brandon J. Baird
    • 1
  • Olga A. Sedelnikova
    • 1
  • William M. Bonner
    • 1
    • 2
    Email author
  1. 1.Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer InstituteNational Institutes of HealthBethesdaUSA
  2. 2.National Cancer InstituteBethesdaUSA

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