Chromosoma

, Volume 118, Issue 3, pp 279–290

Monoallelic gene expression in mammals

  • Irina S. Zakharova
  • Alexander I. Shevchenko
  • Suren M. Zakian
Review

Abstract

Three systems of monoallelic gene expression in mammals are known, namely, X-chromosome inactivation, imprinting, and allelic exclusion. In all three systems, monoallelic expression is regulated epigenetically and is frequently directed by long non-coding RNAs (ncRNAs). This review briefs all three systems of monoallelic gene expression in mammals focusing on chromatin modifications, spatial chromosome organization in the nucleus, and the functioning of ncRNAs.

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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Irina S. Zakharova
    • 1
  • Alexander I. Shevchenko
    • 1
  • Suren M. Zakian
    • 1
    • 2
  1. 1.Siberian Department, Institute of Cytology and GeneticsRussian Academy of SciencesNovosibirskRussia
  2. 2.Institute of Cytology and GeneticsNovosibirskRussia

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