, Volume 116, Issue 6, pp 497–505 | Cite as

Another way to move chromosomes

  • Yuji Chikashige
  • Tokuko Haraguchi
  • Yasushi HiraokaEmail author


A typical way of moving chromosomes is exemplified by mitotic segregation, in which the centromere is directly captured by spindle microtubules. In this study, we highlight another way of moving chromosomes remotely from outside the nucleus, which involves SUN and KASH domain nuclear envelope proteins. SUN and KASH domain protein families are known to connect the nucleus to cytoskeletal networks and play a role in migration and positioning of the nucleus. Recent studies in the fission yeast Schizossacharomyces pombe demonstrated an additional role for the SUN–KASH protein complex in chromosome movements. During meiotic prophase, telomeres are moved to rearrange chromosomes within the nucleus. The SUN–KASH protein complex located in the nuclear envelope is involved in this process. Telomeres are connected to the SUN protein on the nucleoplasmic side, and the dynein motor complex binds to the KASH protein on the cytoplasmic side. Telomeres are then moved along the nuclear envelope using cytoplasmic microtubules. These findings illustrate a general mechanism for transmitting a cytoskeletal driving force to chromosomes across the nuclear envelope.


Nuclear Envelope Fission Yeast Meiotic Prophase Emerin Mitotic Cell Cycle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We would like to thank Abby F. Dernburg, Michael E. Dresser, and Akira Shinohara for providing their results before the publication. This work was supported by grants from the Japanese Ministry MEXT and the Japan Science and Technology Agency.

Supplementary material


(MOV 39.7 MB)


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Yuji Chikashige
    • 1
    • 2
  • Tokuko Haraguchi
    • 1
    • 2
  • Yasushi Hiraoka
    • 1
    • 2
    • 3
    Email author
  1. 1.Kobe Advanced ICT Research CenterNational Institute of Information and Communications TechnologyNishi-kuJapan
  2. 2.Department of BiologyGraduate School of Science, Osaka UniversityOsakaJapan
  3. 3.Graduate School of Frontier BioscienceOsaka UniversityOsakaJapan

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