, Volume 113, Issue 8, pp 409–417 | Cite as

Rephrasing anaphase: separase FEARs shugoshin



Cleavage of the ring-like cohesin complex by separase triggers segregation of sister chromatids in anaphase. This simplistic model has recently been extended by exciting discoveries on three levels: regulation of anaphase by posttranslational modifications and the cohesin protector shugoshin; non-proteolytic roles of separase; and cohesin-independent linkage of sister chromatids.



We apologize to our colleagues whose work could not be cited due to space constraints. O.S. is supported by grants from the Deutsche Forschungsgemeinschaft (DFG; Emmy Noether Program) and from the Human Frontier Science Program.


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© Springer-Verlag 2005

Authors and Affiliations

  1. 1.Department of Molecular Cell BiologyMax Planck Institute of BiochemistryMartinsriedGermany

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